Sch 37137, A NOVEL ANTIFUNGAL COMPOUND PRODUCED BY A MICROMONOSPORA SP TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES

• Published in: Journal of antibiotics Vol. 41; no. 1; pp. 13 - 19
• Main Authors: COOPER, RAYMOND, HORAN, ANN C., GENTILE, FRANK, GULLO, VINCENT, LOEBENBERG, DAVID, MARQUEZ, JOSEPH, PATEL, MAHESH, PUAR, MOHINDAR S., TRUUMEES, IMBI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1988; Japan Antibiotics Research Association
• Subjects: Amino Acids, Diamino - biosynthesis; Amino Acids, Diamino - pharmacology; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - biosynthesis; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Biological and medical sciences; Biotechnology; Chemical Phenomena; Chemistry; Fermentation; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Medical sciences; Micromonospora; Micromonospora - metabolism; Pharmacology. Drug treatments; Production of active biomolecules; Fungi; Antifungal agent; Molecular structure; Taxonomy; Production; Isolation; Fermentation; Biological activity; Physicochemical properties; Thallophyta
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.41.13

A new antifungal compound, Sch 37137, was isolated from the cultured broth of a Micromonospora sp., SCC 1792. Sch 37137 is structurally related to A 19009, a dipeptide previously discovered from a Streptomyces sp. The compound was weakly active against species of Candida and dermatophytes (mean MICs ≥128μg/ml) in Sabouraud dextrose, yeastnitrogen and modified Eagles minimum essential media; however activity against Candida sp. (mean MICs ≥12μg/ml) and dermatophytes (mean MICs ≥0.8μg/ml) significantly improved in MA medium.