Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β ( GSK3B ) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observ...

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Published inFertility and sterility Vol. 87; no. 6; pp. 1473 - 1476
Main Authors Goodarzi, Mark O., M.D., Ph.D, Antoine, Heath J., B.S, Pall, Marita, M.D., Ph.D, Cui, Jinrui, M.S, Guo, Xiuqing, Ph.D, Azziz, Ricardo, M.D., M.B.A., M.P.H
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2007
Subjects
African Continental Ancestry Group - genetics
DNA Primers
European Continental Ancestry Group - genetics
Female
Gene Frequency
Glycogen Synthase Kinase 3 - genetics
Glycogen Synthase Kinase 3 beta
Humans
Internal Medicine
Obstetrics and Gynecology
Polycystic Ovary Syndrome - enzymology
Polycystic Ovary Syndrome - genetics
Polymerase Chain Reaction
Reference Values
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Summary:In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3β ( GSK3B ) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3β contributes to the pathophysiology and inherited basis of PCOS.
Bibliography:ObjectType-Article-1
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ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2006.11.041