A rare form of intoxication: acute methyl ethyl ketone peroxide poisoning

We report two suicidal cases of acute methyl ethyl ketone peroxide (MEKP) poisoning. A woman in her late 60s suffered from oral mucosal erosion, functional impairment of the heart, liver and other organs, pulmonary inflammation, elevated inflammatory markers, pleural effusion, hypoproteinemia and me...

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Bibliographic Details
Published inJournal of international medical research Vol. 50; no. 1; p. 3000605211067694
Main Authors Sun, Cece, Jian, Tianzi, Li, Yaqian, Cui, Siqi, Shi, Longke, Yu, Guangcai, Kan, Baotian, Jian, Xiangdong
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2022
Sage Publications Ltd
SAGE Publishing
Subjects
Butanones
Case Reports
Dysphagia
Esophagus
Female
Hemoperfusion
Humans
Liver
Male
Oral administration
Ostomy
Peroxides
Poisoning
Quality of Life
dysphagia
hemoperfusion
glucocorticoid
Methyl ethyl ketone peroxide
poisoning
esophageal stenosis
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Summary:We report two suicidal cases of acute methyl ethyl ketone peroxide (MEKP) poisoning. A woman in her late 60s suffered from oral mucosal erosion, functional impairment of the heart, liver and other organs, pulmonary inflammation, elevated inflammatory markers, pleural effusion, hypoproteinemia and metabolic acidosis after oral administration of approximately 50 mL of MEKP. After admission, the patient was administered hemoperfusion four times, 8 mg of betamethasone for 6 days and symptomatic support. Hemoperfusion had an obvious effect on the treatment of oral MEKP poisoning. After discharge, the patient developed progressive dysphagia and secondary esophageal stenosis. Supplementary feeding was administered with a gastrostomy tube after the patient was completely unable to eat. A man in his mid-40s developed oropharyngeal mucosal erosion, bronchitis and esophageal wall thickening after oral administration of 40 ml MEKP. After receiving total gastrointestinal dispersal, 80 mg of methylprednisolone was administered for 7 days, and symptomatic supportive treatment was provided. Slight dysphagia was observed after discharge, and there was no major effect on the quality of life. Patients with acute oral MEKP poisoning should be followed up regularly to observe its long-term effects on digestive tract corrosion and stenosis.
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ISSN:0300-0605
1473-2300
DOI:10.1177/03000605211067694