Naphthalene Diimides Carrying Two β-Cyclodextrins Prefer Telomere RNA G-Quadruplex Recognition

Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. Th...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 13; p. 4053
Main Authors Zou, Tingting, Sato, Yuka, Kaneyoshi, Shuma, Mano, Kota, Yasukawa, Rui, Nakano, Yoshifumi, Fujii, Satoshi, Sato, Shinobu, Takenaka, Shigeori
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 23.06.2022
MDPI
Subjects
Binding
Cancer
Cyclodextrin
Cyclodextrins
Diimide
DNA
Hydrogen bonds
Ligands
Naphthalene
naphthalene diimide
nucleobase inclusion
parallel G-quadruplex
RNA
Telomeres
β-cyclodextrins (β-CyDs)
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Summary:Newly synthesized naphthalene diimide carrying two β-cyclodextrins (NDI-β-CyDs) showed improved specificity for the parallel G-quadruplex structure alongside the hybrid G-quadruplex structure. Specifically, the highest binding affinity of NDI-β-CyDs for the telomere RNA G-quadruplex was observed. The binding simulation indicated that β-cyclodextrins might be available for loop nucleobase inclusion under its complex.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27134053