Development of a myelodysplastic/myeloproliferative neoplasm-unclassifiable in a patient with acute myeloid leukemia: a case report and literature review

Myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are a heterogeneous group of hematologic malignancies characterized by dysplastic and myeloproliferative overlapping features in the bone marrow and blood. The occurrence of the disease is related to age, prior history of MPN or MDS, and recent...

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Published inJournal of international medical research Vol. 49; no. 5; p. 3000605211018426
Main Authors Zhao, Meifang, Sun, Jingnan, Liu, Shanshan, Fan, Hongqiong, Fu, Yu, Tan, Yehui, Gao, Sujun
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.05.2021
Sage Publications Ltd
SAGE Publishing
Subjects
Bone Marrow
Case Reports
Hematologic Neoplasms
Humans
Leukemia
Leukemia, Myeloid, Acute - drug therapy
Myelodysplastic Syndromes - drug therapy
Myelodysplastic-Myeloproliferative Diseases
case report
myeloid malignancy
BCR/ABL1 negative
acute myeloid leukemia
Runt-related transcription factor 1/RUNX1 partner transcriptional co-repressor 1 mutation
Myelodysplastic/myeloproliferative neoplasm-unclassifiable
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Summary:Myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are a heterogeneous group of hematologic malignancies characterized by dysplastic and myeloproliferative overlapping features in the bone marrow and blood. The occurrence of the disease is related to age, prior history of MPN or MDS, and recent cytotoxic or growth factor therapy, but it rarely develops after acute myeloid leukemia (AML). We report a rare case of a patient diagnosed with AML with t(8; 21)(q22; q22) who received systematic chemotherapy. After 4 years of follow-up, MDS/MPN-unclassifiable occurred without signs of primary AML recurrence.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0300-0605
1473-2300
DOI:10.1177/03000605211018426