Identification of loci associated with schizophrenia by genome-wide association and follow-up

• Published in: Nature genetics Vol. 40; no. 9; pp. 1053 - 1055
• Main Authors: O'Donovan, Michael C, Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, Nikolov, Ivan, Hamshere, Marian, Carroll, Liam, Georgieva, Lyudmila, Dwyer, Sarah, Holmans, Peter, Marchini, Jonathan L, Spencer, Chris C A, Howie, Bryan, Leung, Hin-Tak, Hartmann, Annette M, Möller, Hans-Jürgen, Morris, Derek W, Shi, YongYong, Feng, GuoYin, Hoffmann, Per, Propping, Peter, Vasilescu, Catalina, Maier, Wolfgang, Rietschel, Marcella, Zammit, Stanley, Schumacher, Johannes, Quinn, Emma M, Schulze, Thomas G, Williams, Nigel M, Giegling, Ina, Iwata, Nakao, Ikeda, Masashi, Darvasi, Ariel, Shifman, Sagiv, He, Lin, Duan, Jubao, Sanders, Alan R, Levinson, Douglas F, Gejman, Pablo V, Cichon, Sven, Nöthen, Markus M, Gill, Michael, Corvin, Aiden, Rujescu, Dan, Kirov, George, Owen, Michael J
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2008; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; Agriculture; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Bipolar Disorder - genetics; brief-communication; Cancer Research; Case-Control Studies; Chromosome Mapping; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetic Predisposition to Disease; Genetic susceptibility; Genetic variation; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Human Genetics; Humans; Kruppel-Like Transcription Factors - genetics; Medical research; Medical sciences; Mental disorders; Meta-analysis; Polymorphism, Single Nucleotide; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Quality control; Risk factors; Schizophrenia; Schizophrenia - genetics; United States; Psychosis; Schizophrenia; Identification; Association; Locus
• ISSN: 1061-4036; 1546-1718
• DOI: 10.1038/ng.201

Michael O'Donovan and colleagues present a genome-wide association study of schizophrenia in 479 cases and 2,937 controls, followed by replication in several cohorts. They report evidence for association for a susceptibility allele near ZNF804A . We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10 −5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support ( P < 5 × 10 −4 ), and the overall pattern of replication was unlikely to occur by chance ( P = 9 × 10 −8 ). Meta-analysis provided strongest evidence for association around ZNF804A ( P = 1.61 × 10 −7 ) and this strengthened when the affected phenotype included bipolar disorder ( P = 9.96 × 10 −9 ).