Comparative immunogenicity of recombinant influenza hemagglutinin (rHA) and trivalent inactivated vaccine (TIV) among persons ≥65 years old

• Published in: Vaccine Vol. 28; no. 2; pp. 379 - 385
• Main Authors: Keitel, W.A., Treanor, J.J., El Sahly, H.M., Gilbert, A., Meyer, A.L., Patriarca, P.A., Cox, M.M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 11.12.2009; Elsevier Limited
• Subjects: Aged; Allergy and Immunology; Antigens; Comparative immunogenicity; Eggs; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Humans; Illnesses; Immune responses; Immunization; Immunogenicity; Influenza vaccines; Influenza Vaccines - administration & dosage; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Licenses; Multicenter Studies as Topic; Older people; Proteins; Recombinant hemagglutinin; Recombinant Proteins - administration & dosage; Recombinant Proteins - adverse effects; Recombinant Proteins - immunology; Seasons; Studies; Surveillance; Swine flu; Vaccines; Vaccines, Inactivated - administration & dosage; Vaccines, Inactivated - adverse effects; Vaccines, Inactivated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - immunology; Influenza vaccines; Immunization; Recombinant hemagglutinin; Immune responses; Comparative immunogenicity
• ISSN: 0264-410X; 1873-2518; 1873-2518
• DOI: 10.1016/j.vaccine.2009.10.037

Alternative substrates for influenza vaccine production are needed to ensure adequate supplies. We evaluated the relative safety and immunogenicity of recombinant hemagglutinin (rHA) or trivalent inactivated vaccine (TIV) among 869 ≥65-year-old subjects in a randomized clinical trial. Virologic surveillance for influenza-like illness (ILI) was conducted during the 2006–2007 epidemic. Vaccines were well tolerated. Seroconversion rates vs. influenza A/H1N1 and H3N2 antigens were superior in the rHA group, but were inferior vs. influenza B; however, results for influenza B are confounded since the vaccine antigens were different. ILI frequencies were low and similar in both groups. Studies assessing relative immunogenicity of vaccines using identical B Ags are warranted.