Correlation Between Average Segment Width and Gamma Passing Rate as a Function of MLC Position Error in Volumetric Modulated Arc Therapy

• Published in: Technology in cancer research & treatment Vol. 20; p. 15330338211059937
• Main Authors: Moon, Young Min, Bae, Sang Il, Han, Moo Jae, Jeon, Wan, Yu, Tosol, Choi, Chul Won, Kim, Jin Young
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Algorithms; Clinical Decision-Making; Disease Management; Gamma Rays; Humans; Lymph nodes; Male; Metastases; Original; Pelvis - pathology; Pelvis - radiation effects; Prostate cancer; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - radiotherapy; Radiotherapy Planning, Computer-Assisted - methods; Radiotherapy, Intensity-Modulated - methods; Radiotherapy, Intensity-Modulated - standards; MLC position error; gamma passing rate; VMAT; average segment width; radiation therapy
• ISSN: 1533-0346; 1533-0338
• DOI: 10.1177/15330338211059937

Objective: This study analyzed the correlation between the average segment width (ASW) and gamma passing rate according to the multi-leaf collimator (MLC) position error. Method: To evaluate the changes in the gamma passing rate according to the MLC position error, 21 volumetric modulated arc therapy (VMAT) plans were generated using pelvic lymph node metastatic prostate cancer patient's data which is sensitive to MLC position errors as they involve several long, narrow, irregular fields. The ASW for each VMAT plan was calculated using our own code developed using Visual Basic for Applications (VBA). The gamma passing rate of the VMAT plan according to the MLC position error was evaluated using ArcCHECK (Sun Nuclear, Melbourne, FL, USA) while inducing symmetric MLC position errors in 0.25 mm intervals from −1 mm to +1 mm in the infinity medical linear accelerator (Elekta AB, Stockholm, Sweden). Finally, we examined the correlation between the change in the passing rate ( γ gradient ) due to the MLC position error and the ASW in VMAT through linear regression analysis using the least squares method. Results: The ASW and γ gradient were found to have a linear correlation according to the MLC position error, and the coefficient of determination was 0.88. For a 1 mm position error of MLC in VMAT, the gamma passing rate improved by approximately 11.9% as the ASW increased by 10 mm. Conclusion: These results are expected to be employed as guidelines to minimize the dose uncertainty due to MLC position error in VMAT.