Diaphragmatic ultrasound findings correlate with dyspnea, exercise tolerance, health-related quality of life and lung function in patients with fibrotic interstitial lung disease

• Published in: BMC pulmonary medicine Vol. 19; no. 1; p. 183
• Main Authors: Santana, Pauliane Vieira, Cardenas, Leticia Zumpano, de Albuquerque, André Luis Pereira, de Carvalho, Carlos Roberto Ribeiro, Caruso, Pedro
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.10.2019; BioMed Central; BMC
• Subjects: Brazil - epidemiology; Causes of; Complications and side effects; Diagnosis; Diagnostic imaging; Diagnostic ultrasonography; Diaphragm; Diaphragm (Anatomy); Diaphragm - diagnostic imaging; Diaphragm - pathology; Diaphragm - physiopathology; Dyspnea; Dyspnea - etiology; Dyspnea - physiopathology; Exercise Tolerance; Female; Health; Health aspects; Humans; Interstitial lung diseases; Lung diseases; Lung Diseases, Interstitial - diagnosis; Lung Diseases, Interstitial - epidemiology; Lung Diseases, Interstitial - physiopathology; Lung Diseases, Interstitial - psychology; Male; Medical examination; Middle Aged; Physiological aspects; Pulmonary fibrosis; Pulmonary ventilation; Quality of Life; Respiratory Function Tests - methods; Respiratory Function Tests - statistics & numerical data; Respiratory tract diseases; Ultrasonography; Ultrasonography - methods; Ultrasonography - statistics & numerical data; Ultrasound imaging; Walk Test - methods; Brazil; Dyspnea; Interstitial lung diseases; Ultrasonography; Diagnostic imaging; Exercise tolerance; Diaphragm; Quality of life
• ISSN: 1471-2466; 1471-2466
• DOI: 10.1186/s12890-019-0936-1

Fibrotic interstitial lung disease (FILD) patients are typically dyspneic and exercise-intolerant with consequent impairment of health-related quality of life (HRQoL). Respiratory muscle dysfunction is among the underlying mechanisms of dyspnea and exercise intolerance in FILD but may be difficult to diagnose. Using ultrasound, we compared diaphragmatic mobility and thickening in FILD cases and healthy controls and correlated these findings with dyspnea, exercise tolerance, HRQoL and lung function. We measured diaphragmatic mobility and thickness during quiet (QB) and deep breathing (DB) and calculated thickening fraction (TF) in 30 FILD cases and 30 healthy controls. We correlated FILD cases' diaphragmatic findings with dyspnea, exercise tolerance (six-minute walk test), lung function and HRQoL (St. George's Respiratory Questionnaire). Diaphragmatic mobility was similar between groups during QB but was lower in FILD cases during DB when compared to healthy controls (3.99 cm vs 7.02 cm; p <  0.01). FILD cases showed higher diaphragm thickness during QB but TF was lower in FILD when compared to healthy controls (70% vs 188%, p <  0.01). During DB, diaphragmatic mobility and thickness correlated with lung function, exercise tolerance and HRQoL, but inversely correlated with dyspnea. Most FILD cases (70%) presented reduced TF, and these patients had higher dyspnea and exercise desaturation, lower HRQoL and lung function. Compared to healthy controls, FILD cases present with lower diaphragmatic mobility and thickening during DB that correlate to increased dyspnea, decreased exercise tolerance, worse HRQoL and worse lung function. FILD cases with reduced diaphragmatic thickening are more dyspneic and exercise-intolerant, have lower HRQoL and lung function.