Pilot Study of Endovascular Delivery of Mesenchymal Stromal Cells in the Aortic Wall in a Pig Model

• Published in: Cell transplantation Vol. 30; p. 9636897211010652
• Main Authors: Li, Ke, Vela, Deborah, Migliati, Elton, da Graca Cabreira, Maria, Wang, Xiaohong, Buja, L Maximilian, Perin, Emerson C.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Aneurysms; Animal models; Aorta; Aortic aneurysms; Brief Communication; Cardiovascular system; Catheters; Cell culture; Hogs; Mesenchymal stem cells; Mesenchyme; Stromal cells; cell transplantation; cardiovascular diseases; abdominal aortic aneurysm; vascular diseases; mesenchymal stromal cells

Abdominal aortic aneurysms (AAAs) have a high mortality. In small-animal models, multipotent mesenchymal stromal cells (MSCs) have shown benefits in attenuating aneurysm formation. However, an optimal cell delivery strategy is lacking. The NOGA system, which targets cell injections in a less-invasiv...