Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 8
• Main Authors: Tsai, Wan-Chi, Lin, Po-Chiao, Tyan, Yu Chang, Huang, Ying Fong, Chen, Wan-Jou, Chen, Ko-Chin, Yang, Jean-Dean, Jhuang, Ting-Syuan, Chung, Tze Wen, Yang, Ming Hui, Chen, Shih-Cheng, Jong, Shiang-Bin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc
• Subjects: Cell Line; Cell Survival - drug effects; Cell Survival - radiation effects; Contrast Media - administration & dosage; Contrast Media - pharmacokinetics; Contrast Media - toxicity; Cytotoxicity; Drug Carriers - chemistry; Drug Delivery Systems; Drug Stability; Drugs; Ethiodized Oil - administration & dosage; Ethiodized Oil - pharmacokinetics; Ethiodized Oil - toxicity; Health aspects; Hep G2 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - radiation effects; Hospitals; Humans; Hyaluronic acid; Hyaluronic Acid - analogs & derivatives; Hydrophobic and Hydrophilic Interactions; Iodine; Iodine Radioisotopes - administration & dosage; Iodine Radioisotopes - pharmacokinetics; Iodine Radioisotopes - toxicity; Isotopes; Labeling; Laboratories; Liver cancer; Medical research; Medicine; Methods; Micelles; Motility; Particle Size; Polyesters; Polyethylene glycol; R&D; Radiation therapy; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - pharmacokinetics; Radiopharmaceuticals - toxicity; Research & development; Rodents; Science; Solubility; Tumors; Vehicles; United States > US; Taiwan

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects,...