Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 8
• Main Authors: Tsai, Wan-Chi, Lin, Po-Chiao, Tyan, Yu Chang, Huang, Ying Fong, Chen, Wan-Jou, Chen, Ko-Chin, Yang, Jean-Dean, Jhuang, Ting-Syuan, Chung, Tze Wen, Yang, Ming Hui, Chen, Shih-Cheng, Jong, Shiang-Bin
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc
• Subjects: Cell Line; Cell Survival - drug effects; Cell Survival - radiation effects; Contrast Media - administration & dosage; Contrast Media - pharmacokinetics; Contrast Media - toxicity; Cytotoxicity; Drug Carriers - chemistry; Drug Delivery Systems; Drug Stability; Drugs; Ethiodized Oil - administration & dosage; Ethiodized Oil - pharmacokinetics; Ethiodized Oil - toxicity; Health aspects; Hep G2 Cells; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - radiation effects; Hospitals; Humans; Hyaluronic acid; Hyaluronic Acid - analogs & derivatives; Hydrophobic and Hydrophilic Interactions; Iodine; Iodine Radioisotopes - administration & dosage; Iodine Radioisotopes - pharmacokinetics; Iodine Radioisotopes - toxicity; Isotopes; Labeling; Laboratories; Liver cancer; Medical research; Medicine; Methods; Micelles; Motility; Particle Size; Polyesters; Polyethylene glycol; R&D; Radiation therapy; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - pharmacokinetics; Radiopharmaceuticals - toxicity; Research & development; Rodents; Science; Solubility; Tumors; Vehicles; United States > US; Taiwan
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2017/4051763

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.