Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol

Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects,...

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Published inBioMed research international Vol. 2017; no. 2017; pp. 1 - 8
Main Authors Tsai, Wan-Chi, Lin, Po-Chiao, Tyan, Yu Chang, Huang, Ying Fong, Chen, Wan-Jou, Chen, Ko-Chin, Yang, Jean-Dean, Jhuang, Ting-Syuan, Chung, Tze Wen, Yang, Ming Hui, Chen, Shih-Cheng, Jong, Shiang-Bin
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Subjects
Cell Line
Cell Survival - drug effects
Cell Survival - radiation effects
Contrast Media - administration & dosage
Contrast Media - pharmacokinetics
Contrast Media - toxicity
Cytotoxicity
Drug Carriers - chemistry
Drug Delivery Systems
Drug Stability
Drugs
Ethiodized Oil - administration & dosage
Ethiodized Oil - pharmacokinetics
Ethiodized Oil - toxicity
Health aspects
Hep G2 Cells
Hepatocytes - drug effects
Hepatocytes - metabolism
Hepatocytes - radiation effects
Hospitals
Humans
Hyaluronic acid
Hyaluronic Acid - analogs & derivatives
Hydrophobic and Hydrophilic Interactions
Iodine
Iodine Radioisotopes - administration & dosage
Iodine Radioisotopes - pharmacokinetics
Iodine Radioisotopes - toxicity
Isotopes
Labeling
Laboratories
Liver cancer
Medical research
Medicine
Methods
Micelles
Motility
Particle Size
Polyesters
Polyethylene glycol
R&D
Radiation therapy
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - pharmacokinetics
Radiopharmaceuticals - toxicity
Research & development
Rodents
Science
Solubility
Tumors
Vehicles
United States > US
Taiwan
Online AccessGet full text

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Abstract Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
AbstractList Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131 I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131 I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used 131I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the 131I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL. We used super(131) I as a radioactive tracer to evaluate the stability, drug delivery, and cell uptake activity of the micelles. The results showed that HA-g-PCL micelles exhibited higher drug encapsulation efficiency and stability in aqueous solutions. In addition, the super(131) I-lipiodol loaded HA-g-PCL micelles had better affinity and higher cytotoxicity compared to HepG2 cells.
Audience Academic
Author Yang, Jean-Dean
Tsai, Wan-Chi
Tyan, Yu Chang
Jhuang, Ting-Syuan
Chen, Shih-Cheng
Lin, Po-Chiao
Chung, Tze Wen
Jong, Shiang-Bin
Yang, Ming Hui
Chen, Wan-Jou
Huang, Ying Fong
Chen, Ko-Chin
AuthorAffiliation 7 Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3 Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan
8 Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
12 Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13 Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2 Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5 Department of Chemistry, Chung Yuan Christian University, Taoyuan 320, Taiwan
14 Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9 Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10 Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
1 Office
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CitedBy_id crossref_primary_10_3390_gels10100663
crossref_primary_10_3390_polym15081835
Cites_doi 10.1016/j.transproceed.2012.11.012
10.1016/0883-2889(92)90168-e
10.1053/sonc.2002.31716
10.1007/s00259-005-1859-z
10.2174/1568011023353679
10.2353/ajpath.2009.080501
10.1038/sj.bjc.6601318
10.1074/jbc.m313178200
10.1016/s0021-9797(02)00082-6
10.3109/10837450.2016.1146296
10.1046/j.0007-1323.2001.02045.x
10.1021/bm051003c
10.1016/j.msec.2015.12.067
10.1007/BF00270463
10.1016/j.yexcr.2010.11.017
10.1016/j.ijpharm.2012.10.030
10.1002/jps.23470
10.1016/j.ijpharm.2010.01.015
10.1002/1097-0142(19950315)75:6<1245::aid-cncr2820750606>3.0.co;2-u
10.1097/00004424-198401000-00009
10.1016/j.jconrel.2013.01.025
10.1021/ja00449a004
10.1016/j.biomaterials.2016.01.049
10.2147/IJN.S39532
10.1007/BF00916581
10.1016/j.jpedsurg.2003.10.011
10.1111/j.1440-1746.2006.04474.x
10.1016/j.jconrel.2016.03.035
10.3390/ijms17040364
10.1016/j.colsurfb.2016.03.019
10.1159/000084510
10.1148/radiology.168.2.2839866
10.1016/j.colsurfb.2011.01.007
10.3109/10717544.2015.1108374
10.1097/00006231-200209000-00005
10.1002/bjs.1800790933
10.1038/nprot.2014.128
ContentType Journal Article
Copyright Copyright © 2017 Shih-Cheng Chen et al.
COPYRIGHT 2017 John Wiley & Sons, Inc.
Copyright © 2017 Shih-Cheng Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2017 Shih-Cheng Chen et al. 2017
Copyright_xml – notice: Copyright © 2017 Shih-Cheng Chen et al.
– notice: COPYRIGHT 2017 John Wiley & Sons, Inc.
– notice: Copyright © 2017 Shih-Cheng Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2017 Shih-Cheng Chen et al. 2017
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References 22
24
25
26
27
28
29
30
31
10
32
11
33
34
13
(14) 2010; 73
35
36
15
37
16
38
17
39
18
19
1
2
3
4
5
(12) 2004; 13
6
7
8
9
40
20
21
14966741 - J Pediatr Surg. 2004 Feb;39(2):203-6; discussion 203-6
21299159 - Acta Gastroenterol Belg. 2010 Oct-Dec;73(4):484-8
23117024 - Int J Pharm. 2013 Jan 30;441(1-2):654-64
14583758 - Br J Cancer. 2003 Nov 3;89(9):1614-9
15229776 - Rom J Gastroenterol. 2004 Jun;13(2):119-24
23498808 - Transplant Proc. 2013 Mar;45(2):688-94
21300529 - Colloids Surf B Biointerfaces. 2011 May 1;84(1):259-66
23493403 - Int J Nanomedicine. 2013;8:971-82
1330198 - Br J Surg. 1992 Sep;79(9):952-4
8406685 - Inflammation. 1993 Aug;17(4):403-15
23400693 - J Pharm Sci. 2013 Apr;102(4):1318-32
27057749 - J Control Release. 2016 May 28;230:64-72
26851390 - Biomaterials. 2016 Apr;84:250-61
15942194 - Cells Tissues Organs. 2005;179(1-2):66-72
3671989 - Rheumatol Int. 1987;7(3):113-22
12678722 - Curr Med Chem Anticancer Agents. 2002 Nov;2(6):715-26
1334953 - Int J Rad Appl Instrum A. 1992 Dec;43(12):1431-5
26916923 - Pharm Dev Technol. 2016 Feb 25;:1-10
20080163 - Int J Pharm. 2010 Apr 15;389(1-2):213-22
26838895 - Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:665-73
25033207 - Nat Protoc. 2014 Aug;9(8):1900-15
19218337 - Am J Pathol. 2009 Mar;174(3):1027-36
14724275 - J Biol Chem. 2004 Apr 30;279(18):18679-87
16032439 - Eur J Nucl Med Mol Imaging. 2005 Aug;32(8):980-9
16724976 - J Gastroenterol Hepatol. 2006 Jun;21(6):941-6
2839866 - Radiology. 1988 Aug;168(2):541-5
26998864 - Colloids Surf B Biointerfaces. 2016 Jul 1;143:27-36
7882276 - Cancer. 1995 Mar 15;75(6):1245-54
6323344 - Invest Radiol. 1984 Jan-Feb;19(1):36-44
26556526 - Drug Deliv. 2016 Jun;23 (5):1818-29
21134368 - Exp Cell Res. 2011 Feb 15;317(4):383-91
23388072 - J Control Release. 2013 Aug 10;169(3):204-10
27043540 - Int J Mol Sci. 2016 Mar 30;17 (4):364
16768412 - Biomacromolecules. 2006 Jun;7(6):1898-903
11951214 - Semin Oncol. 2002 Apr;29(2):160-7
11952584 - Br J Surg. 2002 Apr;89(4):437-41
12195086 - Nucl Med Commun. 2002 Sep;23 (9):837-41
References_xml – ident: 28
  doi: 10.1016/j.transproceed.2012.11.012
– ident: 24
  doi: 10.1016/0883-2889(92)90168-e
– ident: 10
  doi: 10.1053/sonc.2002.31716
– ident: 13
  doi: 10.1007/s00259-005-1859-z
– ident: 6
  doi: 10.2174/1568011023353679
– volume: 73
  start-page: 484
  issue: 4
  year: 2010
  ident: 14
  publication-title: Acta Gastro-Enterologica Belgica
– ident: 20
  doi: 10.2353/ajpath.2009.080501
– ident: 7
  doi: 10.1038/sj.bjc.6601318
– ident: 18
  doi: 10.1074/jbc.m313178200
– ident: 26
  doi: 10.1016/s0021-9797(02)00082-6
– ident: 35
  doi: 10.3109/10837450.2016.1146296
– ident: 8
  doi: 10.1046/j.0007-1323.2001.02045.x
– ident: 29
  doi: 10.1021/bm051003c
– ident: 36
  doi: 10.1016/j.msec.2015.12.067
– ident: 15
  doi: 10.1007/BF00270463
– ident: 19
  doi: 10.1016/j.yexcr.2010.11.017
– ident: 21
  doi: 10.1016/j.ijpharm.2012.10.030
– ident: 31
  doi: 10.1002/jps.23470
– ident: 33
  doi: 10.1016/j.ijpharm.2010.01.015
– ident: 4
  doi: 10.1002/1097-0142(19950315)75:6<1245::aid-cncr2820750606>3.0.co;2-u
– ident: 1
  doi: 10.1097/00004424-198401000-00009
– ident: 32
  doi: 10.1016/j.jconrel.2013.01.025
– ident: 25
  doi: 10.1021/ja00449a004
– volume: 13
  start-page: 119
  issue: 2
  year: 2004
  ident: 12
  publication-title: Romanian Journal of Gastroenterology
– ident: 39
  doi: 10.1016/j.biomaterials.2016.01.049
– ident: 30
  doi: 10.2147/IJN.S39532
– ident: 16
  doi: 10.1007/BF00916581
– ident: 9
  doi: 10.1016/j.jpedsurg.2003.10.011
– ident: 11
  doi: 10.1111/j.1440-1746.2006.04474.x
– ident: 34
  doi: 10.1016/j.jconrel.2016.03.035
– ident: 37
  doi: 10.3390/ijms17040364
– ident: 38
  doi: 10.1016/j.colsurfb.2016.03.019
– ident: 17
  doi: 10.1159/000084510
– ident: 2
  doi: 10.1148/radiology.168.2.2839866
– ident: 22
  doi: 10.1016/j.colsurfb.2011.01.007
– ident: 40
  doi: 10.3109/10717544.2015.1108374
– ident: 5
  doi: 10.1097/00006231-200209000-00005
– ident: 3
  doi: 10.1002/bjs.1800790933
– ident: 27
  doi: 10.1038/nprot.2014.128
– reference: 16724976 - J Gastroenterol Hepatol. 2006 Jun;21(6):941-6
– reference: 14966741 - J Pediatr Surg. 2004 Feb;39(2):203-6; discussion 203-6
– reference: 7882276 - Cancer. 1995 Mar 15;75(6):1245-54
– reference: 21299159 - Acta Gastroenterol Belg. 2010 Oct-Dec;73(4):484-8
– reference: 12678722 - Curr Med Chem Anticancer Agents. 2002 Nov;2(6):715-26
– reference: 15942194 - Cells Tissues Organs. 2005;179(1-2):66-72
– reference: 23498808 - Transplant Proc. 2013 Mar;45(2):688-94
– reference: 6323344 - Invest Radiol. 1984 Jan-Feb;19(1):36-44
– reference: 26556526 - Drug Deliv. 2016 Jun;23 (5):1818-29
– reference: 23117024 - Int J Pharm. 2013 Jan 30;441(1-2):654-64
– reference: 14724275 - J Biol Chem. 2004 Apr 30;279(18):18679-87
– reference: 3671989 - Rheumatol Int. 1987;7(3):113-22
– reference: 19218337 - Am J Pathol. 2009 Mar;174(3):1027-36
– reference: 23388072 - J Control Release. 2013 Aug 10;169(3):204-10
– reference: 16032439 - Eur J Nucl Med Mol Imaging. 2005 Aug;32(8):980-9
– reference: 26851390 - Biomaterials. 2016 Apr;84:250-61
– reference: 11952584 - Br J Surg. 2002 Apr;89(4):437-41
– reference: 12195086 - Nucl Med Commun. 2002 Sep;23 (9):837-41
– reference: 23400693 - J Pharm Sci. 2013 Apr;102(4):1318-32
– reference: 26998864 - Colloids Surf B Biointerfaces. 2016 Jul 1;143:27-36
– reference: 14583758 - Br J Cancer. 2003 Nov 3;89(9):1614-9
– reference: 2839866 - Radiology. 1988 Aug;168(2):541-5
– reference: 23493403 - Int J Nanomedicine. 2013;8:971-82
– reference: 11951214 - Semin Oncol. 2002 Apr;29(2):160-7
– reference: 26838895 - Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:665-73
– reference: 8406685 - Inflammation. 1993 Aug;17(4):403-15
– reference: 16768412 - Biomacromolecules. 2006 Jun;7(6):1898-903
– reference: 1330198 - Br J Surg. 1992 Sep;79(9):952-4
– reference: 1334953 - Int J Rad Appl Instrum A. 1992 Dec;43(12):1431-5
– reference: 21300529 - Colloids Surf B Biointerfaces. 2011 May 1;84(1):259-66
– reference: 20080163 - Int J Pharm. 2010 Apr 15;389(1-2):213-22
– reference: 27043540 - Int J Mol Sci. 2016 Mar 30;17 (4):364
– reference: 27057749 - J Control Release. 2016 May 28;230:64-72
– reference: 15229776 - Rom J Gastroenterol. 2004 Jun;13(2):119-24
– reference: 26916923 - Pharm Dev Technol. 2016 Feb 25;:1-10
– reference: 25033207 - Nat Protoc. 2014 Aug;9(8):1900-15
– reference: 21134368 - Exp Cell Res. 2011 Feb 15;317(4):383-91
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Snippet Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the...
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SubjectTerms Cell Line
Cell Survival - drug effects
Cell Survival - radiation effects
Contrast Media - administration & dosage
Contrast Media - pharmacokinetics
Contrast Media - toxicity
Cytotoxicity
Drug Carriers - chemistry
Drug Delivery Systems
Drug Stability
Drugs
Ethiodized Oil - administration & dosage
Ethiodized Oil - pharmacokinetics
Ethiodized Oil - toxicity
Health aspects
Hep G2 Cells
Hepatocytes - drug effects
Hepatocytes - metabolism
Hepatocytes - radiation effects
Hospitals
Humans
Hyaluronic acid
Hyaluronic Acid - analogs & derivatives
Hydrophobic and Hydrophilic Interactions
Iodine
Iodine Radioisotopes - administration & dosage
Iodine Radioisotopes - pharmacokinetics
Iodine Radioisotopes - toxicity
Isotopes
Labeling
Laboratories
Liver cancer
Medical research
Medicine
Methods
Micelles
Motility
Particle Size
Polyesters
Polyethylene glycol
R&D
Radiation therapy
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - pharmacokinetics
Radiopharmaceuticals - toxicity
Research & development
Rodents
Science
Solubility
Tumors
Vehicles
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Title Preparation and Characterization of Hyaluronic Acid-Polycaprolactone Copolymer Micelles for the Drug Delivery of Radioactive Iodine-131 Labeled Lipiodol
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https://dx.doi.org/10.1155/2017/4051763
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Volume 2017
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