A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery

Abstract Success in the oral delivery of therapeutic insulin can significantly improve the quality of life of diabetic patients who must routinely receive injections of this drug. However, oral absorption of insulin is limited by various physiological barriers and remains a major scientific challeng...

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Published inBiomaterials Vol. 32; no. 36; pp. 9826 - 9838
Main Authors Chen, Mei-Chin, Sonaje, Kiran, Chen, Ko-Jie, Sung, Hsing-Wen
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.12.2011
Subjects
Administration, Oral
Advanced Basic Science
Bioavailability
Biological Transport
Dentistry
Drug Delivery Systems - methods
Formulation technology
Humans
Insulin - administration & dosage
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Paracellular pathway
Polymers - chemistry
Target delivery
Transcellular pathway
Formulation technology
Bioavailability
Target delivery
Paracellular pathway
Transcellular pathway
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Summary:Abstract Success in the oral delivery of therapeutic insulin can significantly improve the quality of life of diabetic patients who must routinely receive injections of this drug. However, oral absorption of insulin is limited by various physiological barriers and remains a major scientific challenge. Various technological solutions have been developed to increase the oral bioavailability of insulin. Having received considerable attention, nano-sized polymeric particles are highly promising for oral insulin delivery. This review article describes the gastrointestinal barriers to oral insulin delivery, including chemical, enzymatic and absorption barriers. The potential transport mechanisms of insulin delivered by nanoparticles across the intestinal epithelium are also discussed. Finally, recent advances in using polymeric nanoparticles for oral insulin delivery and their effects on insulin transport are reviewed, along with their future.
Bibliography:ObjectType-Article-2
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ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2011.08.087