Review of respiratory syncytial virus infection among older adults and transplant recipients

Respiratory syncytial virus (RSV) is a common cause of pulmonary infection among children and has been increasingly recognized as an important respiratory pathogen in older adults and immunocompromised hosts. Among older adults, RSV can lead to exacerbations of underlying lung and cardiac disease. I...

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Published inTherapeutic Advances in Infectious Disease Vol. 9; p. 20499361221091413
Main Authors Villanueva, Daphne-Dominique H., Arcega, Victor, Rao, Mana
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.04.2022
Sage Publications Ltd
SAGE Publishing
Subjects
Antiviral agents
Antiviral drugs
Coronary artery disease
Graft rejection
Heart diseases
Hematopoietic stem cells
Immunocompromised hosts
Immunoprophylaxis
Infections
Lung diseases
Lung transplantation
Monoclonal antibodies
Morbidity
Older people
Respiratory syncytial virus
Respiratory Syncytial Virus Infection
Stem cell transplantation
Vaccine development
Xenografts
older adults
hematopoietic stem cell transplant (HSCT)
respiratory syncytial virus (RSV)
solid organ transplant (SOT)
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Summary:Respiratory syncytial virus (RSV) is a common cause of pulmonary infection among children and has been increasingly recognized as an important respiratory pathogen in older adults and immunocompromised hosts. Among older adults, RSV can lead to exacerbations of underlying lung and cardiac disease. It is also associated with significant morbidity and mortality in hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients and may be associated with acute rejection and chronic lung allograft dysfunction among lung transplant recipients (LTRs). Current treatment options for severe RSV disease are limited, and there is a paucity of guidance on RSV treatment among older adults. This narrative review provides a comprehensive overview of RSV disease in older adults, HSCT recipients, and SOT recipients. Nosocomial spread has been reported, thus highlighting the importance of infection prevention and control measures to prevent outbreaks. Antivirals, monoclonal antibodies for immunoprophylaxis, and vaccine development are underway; however, future research is still needed in these critical areas.
Bibliography:ObjectType-Article-2
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ISSN:2049-9361
2049-937X
DOI:10.1177/20499361221091413