Tissue Engineering Strategies for Fetal Myelomeningocele Repair in Animal Models

Myelomeningocele (MMC), the most severe form of spina bifida, is a common and devastating malformation. Over two decades of experimental work in animal models have led to the development and clinical application of open fetal surgery for the repair of the MMC defect. This approach offers improved ne...

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Bibliographic Details
Published inFetal diagnosis and therapy Vol. 37; no. 3; pp. 197 - 205
Main Authors Watanabe, Miho, Kim, Aimee G., Flake, Alan W.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.04.2015
Subjects
Animals
Care and treatment
Fetal Diseases - surgery
Fetal surgery
Fetal Therapies
Meningomyelocele
Meningomyelocele - surgery
Methods
Minimally Invasive Surgical Procedures
Models, Animal
Review
Tissue Engineering
Transplantation, Autologous
United States
Tissue engineering
Stem cells
Fetal surgery
Minimally invasive techniques
Myelomeningocele
Fetal therapy
Scaffolds
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Summary:Myelomeningocele (MMC), the most severe form of spina bifida, is a common and devastating malformation. Over two decades of experimental work in animal models have led to the development and clinical application of open fetal surgery for the repair of the MMC defect. This approach offers improved neurofunctional outcomes and is now a clinical option for the management of prenatally diagnosed MMC in selected patients. However, there are still opportunities for further improvement in the prenatal treatment of MMC. A less invasive approach would allow for an application earlier in gestation, with a reduction in maternal and fetal risks and the potential for reduced neurological injury. Tissue engineering offers a realistic and appealing alternative approach for the prenatal treatment of MMC. This review discusses the rationale for tissue engineering in MMC, addresses recent experimental progress and describes potential future directions.
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ISBN:9783318054545
3318054542
ISSN:1015-3837
1421-9964
DOI:10.1159/000362931