The Pathophysiology of Focal Hand Dystonia

Abstract Narrative Review Focal hand dystonia is a disabling movement disorder, often task specific, that leads to impaired hand use. In addition to a genetic predisposition, environmental risk factors including repetitive use and musculoskeletal constraints are contributory. Although the underlying...

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Bibliographic Details
Published inJournal of hand therapy Vol. 22; no. 2; pp. 109 - 114
Main Authors Lin, Peter T., MD, Hallett, Mark, MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2009
Elsevier Limited
Subjects
Dystonia
Dystonic Disorders - etiology
Dystonic Disorders - physiopathology
Dystonic Disorders - therapy
Hand
Humans
Hypotheses
Medical imaging
Nervous system
Neural Inhibition - physiology
Neuroimaging
Neuronal Plasticity - physiology
Pathogenesis
Pathophysiology
Physical Medicine and Rehabilitation
Psychomotor Performance - physiology
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Summary:Abstract Narrative Review Focal hand dystonia is a disabling movement disorder, often task specific, that leads to impaired hand use. In addition to a genetic predisposition, environmental risk factors including repetitive use and musculoskeletal constraints are contributory. Although the underlying cause is unknown, recent studies have identified several key mechanisms that may play a part in its genesis. Failure of inhibition, abnormal sensorimotor integration, and maladaptive plasticity seem to be important. Understanding the underlying physiology may lead to the design of novel therapies. Level of Evidence 5.
Bibliography:ObjectType-Article-1
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ObjectType-Review-2
ISSN:0894-1130
1545-004X
DOI:10.1016/j.jht.2008.10.008