Lightwave-reinforced stem cells with enhanced wound healing efficacy

Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here...

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Published inJournal of tissue engineering Vol. 12; p. 20417314211067004
Main Authors Kim, Yu-Jin, Jeon, Hye Ran, Kim, Sung-Won, Kim, Yeong Hwan, Im, Gwang-Bum, Im, Jisoo, Um, Soong Ho, Cho, Sung Min, Lee, Ju-Ro, Kim, Han Young, Joung, Yoon Ki, Kim, Dong-Ik, Bhang, Suk Ho
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.12.2021
Sage Publications Ltd
SAGE Publishing
Subjects
Angiogenesis
Cell adhesion
Cell migration
Inflammation
Inflammatory response
Light therapy
Mesenchyme
Organic light emitting diodes
Original
Reactive oxygen species
Regeneration
Stem cell transplantation
Stem cells
Tissue engineering
Wound healing
human adipose-derived stem cells
wound healing
angiogenesis
Photobiomodulation
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Summary:Comprehensive research has led to significant preclinical outcomes in modified human adipose-derived mesenchymal stem cells (hADSCs). Photobiomodulation (PBM), a technique to enhance the cellular capacity of stem cells, has attracted considerable attention owing to its effectiveness and safety. Here, we suggest a red organic light-emitting diode (OLED)-based PBM strategy to augment the therapeutic efficacy of hADSCs. In vitro assessments revealed that hADSCs basked in red OLED light exhibited enhanced angiogenesis, cell adhesion, and migration compared to naïve hADSCs. We demonstrated that the enhancement of cellular capacity was due to an increased level of intracellular reactive oxygen species. Furthermore, accelerated healing and regulated inflammatory response was observed in mice transplanted with red light-basked hADSCs. Overall, our findings suggest that OLED-based PBM may be an easily accessible and attractive approach for tissue regeneration that can be applied to various clinical stem cell therapies.
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These authors contributed equally to this work.
ISSN:2041-7314
2041-7314
DOI:10.1177/20417314211067004