Dairy foods intake and risk of Parkinson's disease: a dose-response meta-analysis of prospective cohort studies

• Published in: European journal of epidemiology Vol. 29; no. 9; pp. 613 - 619
• Main Authors: Jiang, Wenjie, Ju, Chuanxia, Jiang, Hong, Zhang, Dongfeng
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.09.2014; Springer Netherlands
• Subjects: Animals; Biological and medical sciences; Cardiology; Cheese - adverse effects; Cheese industry; Cohort studies; Dairy Products; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diet; Dietary Fats - administration & dosage; Disease risk; Dose response relationship; Dose-Response Relationship, Drug; Epidemiology; Female; Food intake; General aspects; Humans; Infectious Diseases; Male; Medical sciences; Medicine; Medicine & Public Health; META-ANALYSIS; Middle Aged; Milk; Milk - adverse effects; Miscellaneous; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Oncology; Parkinson disease; Parkinson Disease - epidemiology; Parkinson Disease - etiology; Parkinson Disease - prevention & control; Pesticides; Prospective Studies; Public Health; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk Assessment; Risk Factors; Surveys and Questionnaires; Yogurt; Yogurt - adverse effects; Dairy foods; Parkinson’s disease; Meta-analysis; Nervous system diseases; Parkinson's disease; Evidence-based practice; Parkinson disease; Dairy product; Risk; Epidemiology; Evidence-based medicine; Cerebral disorder; Metaanalysis; Prospective; Food intake; Cohort study; Central nervous system disease; Risk factor; Degenerative disease; Dose; Public health; Extrapyramidal syndrome; Food
• ISSN: 0393-2990; 1573-7284; 1573-7284
• DOI: 10.1007/s10654-014-9921-4

Dairy foods have been linked to Parkinson's disease (PD), and a meta-analysis of prospective cohort studies on dairy foods intake and PD risk was conducted. Eligible studies were identified in a literature search of EMBASE and PubMed up to April 2014. Seven results from prospective studies were included, including 1,083 PD cases among 304,193 subjects. The combined risk of PD for highest vs. lowest level of dairy foods intake was 1.40 (1.20-1.63) overall, 1.66 (1.29-2.14) for men and 1.15 (0.85-1.56) for women. For highest vs. lowest level, the PD risk was 1.45 (1.23-1.73) for milk, 1.26 (0.99-1.60) for cheese, 0.95 (0.76-1.20) for yogurt and 0.76 (0.51-1.13) for butter. The linear dose-response relationship showed that PD risk increased by 17 % [1.17 (1.06-1.30)] for every 200 g/day increment in milk intake (Pfor non-linearity = 0.22), and 13 % [1.13 (0.91-1.40)] for every 10 g/day increment in cheese intake (P for non-linearity = 0.39). The absolute risk differences were estimated to be 2-4 PD cases per 100,000 person-years for every 200 g/day increment in milk intake, and 1-3 PD cases per 100,000 person-years for every 10 g/day increment in cheese intake. Dairy foods (milk, cheese) might be positively associated with increased risk of PD, especially for men.