What do we measure when we measure cell-associated HIV RNA

Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. This review provides an update on some recent insights in the biology and clinical utility of...

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Bibliographic Details
Published inRetrovirology Vol. 15; no. 1; p. 13
Main Authors Pasternak, Alexander O, Berkhout, Ben
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 29.01.2018
BioMed Central
BMC
Subjects
Anti-HIV Agents - therapeutic use
Antiretroviral therapy
Antiviral agents
CD4-Positive T-Lymphocytes - virology
Cell-associated HIV RNA
DNA, Viral - analysis
Drug therapy
Genetic aspects
HIV (Viruses)
HIV cure
HIV Infections - drug therapy
HIV Infections - virology
HIV persistence
HIV reservoir
HIV-1 - drug effects
HIV-1 - genetics
HIV-1 - growth & development
Humans
Physiological aspects
Proviruses - genetics
Proviruses - growth & development
Review
RNA, Viral - analysis
Virological biomarker
Virus Latency
Virus Replication
Netherlands
Cell-associated HIV RNA
Virological biomarker
HIV reservoir
HIV cure
Antiretroviral therapy
HIV persistence
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Summary:Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. This review provides an update on some recent insights in the biology and clinical utility of this biomarker. We discuss a number of important considerations to be taken into account when interpreting CA HIV RNA measurements, as well as different methods to measure this biomarker.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1742-4690
1742-4690
DOI:10.1186/s12977-018-0397-2