Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 30; no. 4; pp. 443 - 448
• Main Authors: Sugihara, Kohei, B.A, Yamanaka-Okumura, Hisami, Ph.D, Teramoto, Arisa, M.S, Urano, Eri, M.S, Katayama, Takafumi, Ph.D, Mori, Hiroki, M.D., Ph.D, Utsunomiya, Tohru, M.D., Ph.D, Shimada, Mitsuo, M.D., Ph.D, Takeda, Eiji, M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2014; Elsevier; Elsevier Limited
• Subjects: Adult; Age; Age Factors; Aged; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Bilirubin - blood; Biochemistry; Biological and medical sciences; Blood; Body mass index; Calorimetry; Calorimetry, Indirect; Carcinoma, Hepatocellular - surgery; Energy Metabolism; Fatty Acids, Nonesterified - blood; Feeding. Feeding behavior; Female; Food; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatectomy; Hepatitis; Hospitalization; Hospitals; Humans; Late evening snack; Liver; Liver - surgery; Liver cancer; Liver cirrhosis; Liver Neoplasms - surgery; Liver Transplantation; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Living Donors - classification; Male; Medical sciences; Metabolism; Middle Aged; Non-esterified fatty acids; Non-protein respiratory quotient; Nutritional management; Nutritional Status; Other diseases. Semiology; Patients; Pediatrics; Postoperative Care; Postoperative Period; Proteins; Surgery; Surgical techniques; Variance analysis; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Japan; Nutritional management; Non-protein respiratory quotient; Non-esterified fatty acids; Hepatectomy; Late evening snack; Resection; Nutrition; Evening; Lipids; Hepatic disease; Fatty acids; Recovery; Protein; Fatty liver; Digestive diseases; Respiratory quotient
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2013.09.012

Abstract Objective Perioperative nutritional care is important to maintain preoperative and postoperative nutritional status. However, few reports have investigated energy metabolism after hepatectomy. The aim of this study was to determine differences in energy metabolism, blood biochemistry, and nutritional status before and after liver resection in patients with hepatocellular carcinoma (HCC) and healthy living donors for liver transplantation. Methods Eighteen hospitalized patients with HCC group and 13 living donors for liver transplantation (donor group) were enrolled in this study. The donor group was divided into two groups on the basis of age; Y-donor group (age < 40 y, n = 7), and O-donor group (age ≥ 40 y, n = 6). Energy metabolism was measured by indirect calorimetry at preoperative day and postoperative day (POD) 7 and 14, and blood biochemistry was also examined. Results Recovery of non-protein respiratory quotient (npRQ) and blood biochemical data such as total bilirubin, aspartate aminotransferase and alanine aminotransferase levels were observed in Y-donor group on POD 14. However, although biochemical data improved in the HCC and O-donor group, npRQ remained unchanged on POD 14. Conclusions Improvement of npRQ took longer than blood biochemical data in patients with HCC and older donors. Because the recovery of npRQ is associated with donor age, careful nutritional management may be required for a longer time depending on the pathophysiological condition of each patient after hepatectomy.