Ecological and Evolutionary Consequences of Anticancer Adaptations

Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for anima...

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Published iniScience Vol. 23; no. 11; p. 101716
Main Authors Boutry, Justine, Dujon, Antoine M., Gerard, Anne-Lise, Tissot, Sophie, Macdonald, Nick, Schultz, Aaron, Biro, Peter A., Beckmann, Christa, Hamede, Rodrigo, Hamilton, David G., Giraudeau, Mathieu, Ujvari, Beata, Thomas, Frédéric
Format Journal Article
LanguageEnglish
Published Elsevier Inc 20.11.2020
Elsevier
Subjects
Biological Sciences
Cancer Systems Biology
Evolutionary Biology
Evolutionary Ecology
Life Sciences
Review
Biological Sciences
Evolutionary Biology
Evolutionary Ecology
Cancer Systems Biology
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Summary:Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research. [Display omitted] Biological Sciences; Evolutionary Biology; Evolutionary Ecology; Cancer Systems Biology
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
PMCID: PMC7674277
These authors contributed equally
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2020.101716