Focal Type 2 Autoimmune Pancreatitis Mimicking Pancreatic Cancer: Treatment with Neoadjuvant Chemotherapy and Surgery

• Published in: Internal Medicine Vol. 62; no. 17; pp. 2499 - 2505
• Main Authors: Maeda, Nobuhisa, Tanoue, Shiroh, Fujino, Yusuke, Hinokuchi, Makoto, Arima, Shiho, Sasaki, Fumisato, Hashimoto, Shinichi, Kanmura, Shuji, Higashi, Michiyo, Ido, Akio
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.09.2023; Japan Science and Technology Agency
• Subjects: Adenocarcinoma; Autoimmune Diseases - diagnosis; Autoimmune Diseases - drug therapy; Autoimmune Pancreatitis - diagnosis; Autoimmune Pancreatitis - drug therapy; Case Report; Chemotherapy; Cytology; Diagnosis; Humans; Internal medicine; Male; Middle Aged; neoadjuvant chemotherapy; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - surgery; Pancreatitis; Surgery; type 2 autoimmune pancreatitis; neoadjuvant chemotherapy; pancreatic cancer; type 2 autoimmune pancreatitis
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.0224-22

A 51-year-old man was referred to our hospital for the further examination of main pancreatic duct interruption. Imaging findings showed a 25-mm-diameter mass lesion located in the pancreatic head. Endoscopic ultrasonography (EUS)-guided fine-needle aspiration (FNA) was performed on the mass. Cytology suggested adenocarcinoma, but the histological diagnosis was not confirmed. We made a comprehensive diagnosis of resectable pancreatic cancer. The mass shrank after preoperative adjuvant chemotherapy, and the patient underwent surgery. The final pathological diagnosis was type 2 autoimmune pancreatitis (AIP). Two years after surgery, AIP had not recurred in the remaining pancreas.