Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions

• Published in: The Journal of biological chemistry Vol. 281; no. 32; pp. 22847 - 22854
• Main Authors: Arita, Makoto, Oh, Sungwhan F., Chonan, Tomomichi, Hong, Song, Elangovan, Siva, Sun, Yee-Ping, Uddin, Jasim, Petasis, Nicos A., Serhan, Charles N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.08.2006; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Cytokines - metabolism; Eicosapentaenoic Acid - analogs & derivatives; Eicosapentaenoic Acid - antagonists & inhibitors; Eicosapentaenoic Acid - chemistry; Female; Humans; Hydroxyprostaglandin Dehydrogenases - chemistry; Lung - metabolism; Mice; Mice, Inbred C57BL; Models, Molecular; Neutrophils - metabolism; Recombinant Proteins - chemistry

The resolvins (Rv) are lipid mediators derived from omega-3 polyunsaturated fatty acids that act within a local inflammatory milieu to stop leukocyte recruitment and promote resolution. Resolvin E1 (RvE1; (5S,12R,18R)-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is an oxygenase product derive...