Serotonin selectively influences moral judgment and behavior through effects on harm aversion

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 40; pp. 17433 - 17438
• Main Authors: Crockett, Molly J., Clark, Luke, Hauser, Marc D., Robbins, Trevor W.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 05.10.2010; National Acad Sciences
• Series: From the Cover
• Subjects: Adult; Antidepressants; Behavior; Behavior - drug effects; Behavior - physiology; Behavioral neuroscience; Biological Sciences; Citalopram - pharmacology; Decision Making - drug effects; Drug interactions; Empathy; Fairness; Fear; Humans; Judgment; Male; Moral judgment; Morals; Neuropsychological Tests; Personality traits; Placebo effect; Placebos; Prosocial behavior; Psychopharmacology; Saliency; Serotonin; Serotonin - metabolism; Serotonin Uptake Inhibitors - pharmacology; Social Behavior; Transponders
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1009396107

Aversive emotional reactions to real or imagined social harms infuse moral judgment and motivate prosocial behavior. Here, we show that the neurotransmitter serotonin directly alters both moral judgment and behavior through increasing subjects' aversion to personally harming others. We enhanced serotonin in healthy volunteers with citalopram (a selective serotonin reuptake inhibitor) and contrasted its effects with both a pharmacological control treatment and a placebo on tests of moral judgment and behavior. We measured the drugs' effects on moral judgment in a set of moral 'dilemmas' pitting utilitarian outcomes (e.g., saving five lives) against highly aversive harmful actions (e.g., killing an innocent person). Enhancing serotonin made subjects more likely to judge harmful actions as forbidden, but only in cases where harms were emotionally salient. This harm-avoidant bias after citalopram was also evident in behavior during the ultimatum game, in which subjects decide to accept or reject fair or unfair monetary offers from another player. Rejecting unfair offers enforces a fairness norm but also harms the other player financially. Enhancing serotonin made subjects less likely to reject unfair offers. Furthermore, the prosocial effects of citalopram varied as a function of trait empathy. Individuals high in trait empathy showed stronger effects of citalopram on moral judgment and behavior than individuals low in trait empathy. Together, these findings provide unique evidence that serotonin could promote prosocial behavior by enhancing harm aversion, a prosocial sentiment that directly affects both moral judgment and moral behavior.