Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

• Published in: Reproductive biology and endocrinology Vol. 17; no. 1; p. 65
• Main Authors: Cao, Yubin, Li, Zeping, Jiang, Wenyu, Ling, Yan, Kuang, Haibin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.08.2019; BioMed Central; BMC
• Subjects: Animals; Cell receptors; Cellular signal transduction; Female; G proteins; Health aspects; KISS1R; Kisspeptin; Kisspeptins - genetics; Kisspeptins - metabolism; Kisspeptins - physiology; Male; Neuropeptides; Oocytes - growth & development; Ovary; Ovary - growth & development; Ovary - metabolism; Ovulation; Physiological aspects; Placenta; Placenta - metabolism; Placenta - physiology; Pregnancy; Receptors, Kisspeptin-1 - genetics; Receptors, Kisspeptin-1 - metabolism; Receptors, Kisspeptin-1 - physiology; Reproduction (Biology); Review; Spermatogenesis; Testis; Testis - metabolism; Uterus; Uterus - metabolism; China; Kisspeptin; Testis; KISS1R; Ovary; Placenta; Uterus
• ISSN: 1477-7827; 1477-7827
• DOI: 10.1186/s12958-019-0511-x

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.