Intraoperative Platelet-Rich Plasma Does Not Improve Outcomes of Total Knee Arthroplasty

• Published in: The Journal of arthroplasty Vol. 29; no. 12; pp. 2337 - 2341
• Main Authors: Morishita, Masayuki, Ishida, Kazunari, Matsumoto, Tomoyuki, Kuroda, Ryosuke, Kurosaka, Masahiro, Tsumura, Nobuhiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2014
• Subjects: Administration, Topical; Aged; Aged, 80 and over; Arthralgia - prevention & control; Arthroplasty, Replacement, Knee - methods; bleeding; Female; functional score; Hemostasis, Surgical - methods; Hemostatics - administration & dosage; Humans; Intercellular Signaling Peptides and Proteins - administration & dosage; Knee Joint - surgery; Male; Orthopedics; Osteoarthritis, Knee - surgery; Osteoarthritis, Knee - therapy; Pain, Postoperative - prevention & control; Platelet-Rich Plasma; postoperative recovery; Range of Motion, Articular; total knee arthroplasty; Treatment Outcome; total knee arthroplasty; bleeding; postoperative recovery; platelet-rich plasma; functional score
• ISSN: 0883-5403; 1532-8406; 1532-8406
• DOI: 10.1016/j.arth.2014.04.007

This randomized controlled study was conducted to assess the effects of platelet-rich plasma (PRP) on outcomes of total knee arthroplasty (TKA). Forty patients who underwent unilateral TKA were evaluated prospectively; 20 received intraoperative PRP and 20 served as control subjects. The results showed no significant differences in reduction of bleeding, range of motion, swelling around the knee joint, muscle power recovery, pain, Knee Society Scores, and Knee Injury and Osteoarthritis Outcome Score between the 2 groups. Additionally, no distinct clinical characteristics were found in patients who received intraoperative PRP. Therefore, we conclude that intraoperative PRP does not improve outcomes of TKA.