Visceral Fat-Reducing Effect and Safety of Continuous Consumption of Beverage Containing Resistant Maltodextrin: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial

• Published in: Journal of Nutritional Science and Vitaminology Vol. 66; no. 5; pp. 417 - 426
• Main Authors: KITAGAWA, Machiko, NAKAGAWA, Shinsuke, SUZUKI, Takuto, KISHIMOTO, Yuka, KANAHORI, Sumiko, HATAKEYAMA, Yoshitaka, TOMITA, Shimpei, FUKUHARA, Ikuo
• Format: Journal Article
• Language: English
• Published: Center for Academic Publications Japan 31.10.2020
• Subjects: free life; healthy adult; indigestible dextrin; insulin resistance; long-term human study; obesity; soluble dietary fiber
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.66.417

Obesity is regarded as a global concern with increasing prevalence, most notably in developed countries. Metabolic syndrome is a predictor of cardiovascular disease and type 2 diabetes mellitus and is defined as the accumulation of multiple risk factors caused by abdominal visceral obesity. Resistant maltodextrin (RMD) is a soluble dietary fiber that has been shown to reduce visceral fat in long-term clinical trials when continuously administered at 10 g, three times daily. Herein, we evaluated the effects of long-term consumption of 5 g RMD three times daily. A total of 140 healthy adults were randomly assigned to two intervention groups for a 12-wk randomized, double-blind, placebo-controlled, parallel-group trial. Participants ingested a test beverage containing 5 g RMD or a placebo beverage without RMD. Interviews, anthropometric measurements, physiological examination, blood tests, and urinalyses were conducted at baseline and every 4 wk during the trial. Computed tomography scans were performed at baseline and at the end of week 8 and 12. Results showed that abdominal visceral fat area (VFA) significantly decreased in the test group from 105.33±26.83 cm2 at baseline to 101.15±24.33 cm2 at week 12. Further, a significant difference was observed in the VFA between the test and control groups (p<0.05), confirming the function of continuous RMD consumption in reducing abdominal visceral fat. Furthermore, neither serious adverse events nor adverse clinical findings were observed in the blood or urine tests following consumption of RMD, suggesting that continuous consumption of RMD containing beverages is safe.