Studies of the CETP TaqIB and ApoE Polymorphisms in Southern Thai Subjects with the Metabolic Syndrome

• Published in: Biochemical genetics Vol. 53; no. 7-8; pp. 184 - 199
• Main Authors: Jeenduang, Nutjaree, Porntadavity, Sureerut, Nuinoon, Manit, Horpet, Dararat, Thepkwan, Nongyao, Thaworn, Pattamawadee, Theanmontri, Suporn
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2015; Springer Nature B.V
• Subjects: Adult; adults; Alleles; apolipoprotein E; Apolipoproteins E - genetics; Asian Continental Ancestry Group; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cholesterol; Cholesterol Ester Transfer Proteins - genetics; Cholesterol, HDL - metabolism; cholesteryl ester transfer protein; Female; Genetic Association Studies; Genetic factors; Genetic Predisposition to Disease; Human Genetics; Humans; Male; Medical Microbiology; Metabolic disorders; metabolic syndrome; Metabolic Syndrome - genetics; Middle Aged; National Cholesterol Education Program; odds ratio; Original Article; polymerase chain reaction; Polymorphism, Genetic; Regression analysis; restriction fragment length polymorphism; Risk factors; Thailand; Zoology; Thailand; Metabolic syndrome; Polymorphism
• ISSN: 0006-2928; 1573-4927
• DOI: 10.1007/s10528-015-9680-2

Several genetic factors have been investigated responsible for metabolic syndrome (MetS). The aim of this study was to investigate the association between cholesteryl ester transfer protein (CETP) TaqIB and apolipoprotein E (ApoE) polymorphisms and MetS in 378 subjects from Southern Thailand. Subjects were divided into MetS+ (n = 121) and MetS− (n = 257) groups according to the criteria of National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII). The CETP TaqIB and ApoE polymorphisms were analyzed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) technique. Logistic regression analysis revealed no association of CETP TaqIB and ApoE variants with MetS, after adjustment for age and sex. However, ε4 allele had a significantly increased odds ratio (OR) of reduced high-density lipoprotein–cholesterol (HDL-C) levels when compared with ε3 allele (OR 1.91; 95 % CI 1.11–3.29, p = 0.020). This suggests that CETP TaqIB and ApoE polymorphisms may not be considered as genetic risk factors for MetS in a Southern Thai population. However, ε4 allele which is associated with one metabolic component, low HDL-C levels, might predispose the subjects to develop metabolic disturbances.