High Performance Marine and Terrestrial Bioadhesives and the Biomedical Applications They Have Inspired

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 24; p. 8982
• Main Author: Melrose, James
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.12.2022; MDPI
• Subjects: Adhesion; Adhesives; Adhesives - pharmacology; Animals; Aqueous environments; Artificial Intelligence; barnacles; Biological products; Biomedical materials; Biomolecules; Biosensors; Bivalvia; caddis-fly fly; Diabetes mellitus; Electronics; Environmental conditions; Exudates; Exudation; Food; Fresh water; gecko; Heart surgery; marine bioadhesive; mussel; Orthopedics; Photonics; Review; Silk; Skin; slug; Soft tissues; Structural engineers; Sutures; Tissue Adhesives - chemistry; Toads; Tongue; Ulcers; Wound healing; Australia; catechol; sericin; fibroin; gecko; caddis-fly fly; seroin; L-DOPA; barnacles; marine bioadhesive; mussel; spider silk; slug
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27248982

This study has reviewed the naturally occurring bioadhesives produced in marine and freshwater aqueous environments and in the mucinous exudates of some terrestrial animals which have remarkable properties providing adhesion under difficult environmental conditions. These bioadhesives have inspired the development of medical bioadhesives with impressive properties that provide an effective alternative to suturing surgical wounds improving closure and healing of wounds in technically demanding tissues such as the heart, lung and soft tissues like the brain and intestinal mucosa. The Gecko has developed a dry-adhesive system of exceptional performance and has inspired the development of new generation re-usable tapes applicable to many medical procedures. The silk of spider webs has been equally inspiring to structural engineers and materials scientists and has revealed innovative properties which have led to new generation technologies in photonics, phononics and micro-electronics in the development of wearable biosensors. Man made products designed to emulate the performance of these natural bioadhesive molecules are improving wound closure and healing of problematic lesions such as diabetic foot ulcers which are notoriously painful and have also found application in many other areas in biomedicine. Armed with information on the mechanistic properties of these impressive biomolecules major advances are expected in biomedicine, micro-electronics, photonics, materials science, artificial intelligence and robotics technology.