Antioxidant properties of omeprazole

• Published in: FEBS letters Vol. 382; no. 1; pp. 189 - 192
• Main Authors: Lapenna, Domenico, Gioia, Sergio de, Ciofani, Giuliano, Festi, Davide, Cuccurullo, Franco
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 11.03.1996
• Subjects: Anti-Ulcer Agents - pharmacology; Antioxidant; Antioxidants - pharmacology; Ascorbic Acid - pharmacology; beta Carotene; Carotenoids - metabolism; Chlorides; Copper; Copper - pharmacology; Deoxyribose - metabolism; Ferric Compounds - pharmacology; Hydrogen-Ion Concentration; Hypochlorous acid; Hypochlorous Acid - pharmacology; Iron; Omeprazole; Omeprazole - pharmacology; Oxidation-Reduction - drug effects; Oxidative stress; Omeprazole; Oxidative stress; Iron; Hypochlorous acid; Copper; Antioxidant

Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous a...