Antioxidant properties of omeprazole

• Published in: FEBS letters Vol. 382; no. 1; pp. 189 - 192
• Main Authors: Lapenna, Domenico, Gioia, Sergio de, Ciofani, Giuliano, Festi, Davide, Cuccurullo, Franco
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 11.03.1996
• Subjects: Anti-Ulcer Agents - pharmacology; Antioxidant; Antioxidants - pharmacology; Ascorbic Acid - pharmacology; beta Carotene; Carotenoids - metabolism; Chlorides; Copper; Copper - pharmacology; Deoxyribose - metabolism; Ferric Compounds - pharmacology; Hydrogen-Ion Concentration; Hypochlorous acid; Hypochlorous Acid - pharmacology; Iron; Omeprazole; Omeprazole - pharmacology; Oxidation-Reduction - drug effects; Oxidative stress; Omeprazole; Oxidative stress; Iron; Hypochlorous acid; Copper; Antioxidant
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(96)00155-X

Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 μM at pH of 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCl scavenger ascorbate. Moreover, 10 and 50 μM OM inhibit significantly both iron-and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.