function of the Egr1 transcription factor in cartilage formation and adaptation to microgravity in zebrafish, Danio rerio
Osteoporosis is one of the major concerns for an ageing human population and for passengers on long-term space flights. Teleosts represent a potentially interesting alternative for studying bone physiology. In zebrafish (Danio rerio), the cartilaginous elements that form the pharyngeal arches derive...
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Published in | Journal of applied ichthyology Vol. 26; no. 2; pp. 239 - 244 |
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Main Authors | , , , , , , , |
Format | Journal Article Web Resource |
Language | English |
Published |
Oxford, UK
Oxford, UK : Blackwell Publishing Ltd
01.04.2010
Blackwell Publishing Ltd Blackwell Publishing |
Subjects | |
Online Access | Get full text |
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Summary: | Osteoporosis is one of the major concerns for an ageing human population and for passengers on long-term space flights. Teleosts represent a potentially interesting alternative for studying bone physiology. In zebrafish (Danio rerio), the cartilaginous elements that form the pharyngeal arches derive from cranial neural crest cells, whose proper patterning and morphogenesis require reciprocal interactions with other tissue types such as pharyngeal endoderm, ectoderm and mesoderm. We show how the zebrafish can be used to study the function of signal transduction pathways, such as the Fgf pathway, or that of particular genes, such as the zinc finger transcription factor Egr1, in pharyngeal skeleton formation and maintenance. We investigate the changes caused by microgravity and chemical treatments on zebrafish. We analyze early gene expression modification using whole genome microarray experiments and the long-term consequences by staining bone structures. |
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Bibliography: | http://dx.doi.org/10.1111/j.1439-0426.2010.01413.x istex:6672EB5A6A9A02FB070AF773DA7A79EBC95E79FC ArticleID:JAI1413 ark:/67375/WNG-XQJR29R7-M Current address: Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Conference-1 ObjectType-Feature-3 SourceType-Conference Papers & Proceedings-2 scopus-id:2-s2.0-77954199825 |
ISSN: | 0175-8659 1439-0426 1439-0426 |
DOI: | 10.1111/j.1439-0426.2010.01413.x |