Decoding sequential finger movements from preparatory activity in higher-order motor regions: a functional magnetic resonance imaging multi-voxel pattern analysis

• Published in: The European journal of neuroscience Vol. 42; no. 10; pp. 2851 - 2859
• Main Authors: Nambu, Isao, Hagura, Nobuhiro, Hirose, Satoshi, Wada, Yasuhiro, Kawato, Mitsuo, Naito, Eiichi
• Format: Journal Article
• Language: English
• Published: France Blackwell Publishing Ltd 01.11.2015
• Subjects: Adult; Brain - physiology; Brain Mapping - methods; Female; Fingers - physiology; functional magnetic resonance imaging decoding; human brain; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - methods; Male; Motor Activity; Motor Cortex - physiology; motor sequence; movement preparation; Psychomotor Performance - physiology; Young Adult; human brain; functional magnetic resonance imaging decoding; motor sequence; movement preparation
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.13063

Performing a complex sequential finger movement requires the temporally well‐ordered organization of individual finger movements. Previous behavioural studies have suggested that the brain prepares a whole sequence of movements as a single set, rather than the movements of individual fingers. However, direct neuroimaging support for this hypothesis is lacking and, assuming it to be true, it remains unclear which brain regions represent the information of a prepared sequence. Here, we measured brain activity with functional magnetic resonance imaging while 14 right‐handed healthy participants performed two types of well‐learned sequential finger movements with their right hands. Using multi‐voxel pattern analysis, we examined whether the types of the forthcoming sequence could be predicted from the preparatory activities of nine regions of interest, which included the motor, somatosensory and posterior parietal regions in each hemisphere, bilateral visual cortices, cerebellum and basal ganglia. We found that, during preparation, the activity of the contralateral motor regions could predict which of the two sequences would be executed. Further detailed analysis revealed that the contralateral dorsal premotor cortex and supplementary motor area were the key areas that contributed to the prediction consistently across participants. These contrasted with results from execution‐related brain activity where a performed sequence was successfully predicted from the activities in the broad cortical sensory‐motor network, including the bilateral motor, parietal and ipsilateral somatosensory cortices. Our study supports the hypothesis that temporary well‐organized sequences of movements are represented as a set in the brain, and that preparatory activity in higher‐order motor regions represents information about upcoming motor actions. Using fMRI multi‐voxel pattern analysis, this study showed that types of sequential finger movements can be predicted from preparatory activity in contralateral motor regions. Further, activity in the supplementary motor area and dorsal premotor cortex contributed to this prediction. This suggests that in humans, sequential finger movements are represented in higher‐order motor regions as a single action set when planning movements.