Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan
The relationship between Borna disease virus (BDV) infection and schizophrenia in the clinical time course was investigated. By nested reverse‐transcribed polymerase chain reaction (RT‐PCR) and Western blotting, BDV‐specific RNA and anti‐BDV antibodies were examined in the EDTA‐treated blood from 67...
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Published in | Acta psychiatrica Scandinavica Vol. 96; no. 6; pp. 412 - 415 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.12.1997
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | The relationship between Borna disease virus (BDV) infection and schizophrenia in the clinical time course was investigated. By nested reverse‐transcribed polymerase chain reaction (RT‐PCR) and Western blotting, BDV‐specific RNA and anti‐BDV antibodies were examined in the EDTA‐treated blood from 67 schizophrenic patients (according to DSM‐III‐R) in Japan. A significantly higher proportion (45%) of anti‐BDV antibody and/ or BDV RNA carriers were found among these 67 schizophrenic patients than in 26 controls (0%). There were no apparent associations of BDV infection with age, age at onset, period of hospitalization, accompanying somatic diseases, a past history of tuberculosis, a history of transfusion, a family history, or doses of psychotropic drugs. It is possible that, at least, BDV infection in schizophrenic patients may not be a nosocomial (hospital‐acquired) infection, although the route of BDV infection in humans remains unidentified. More studies on the relationship between BDV infection and clinical psychosomatic features should be performed in order to elucidate the pathogenesis of schizophrenia. |
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Bibliography: | ark:/67375/WNG-DX1KCQ8S-G istex:4A068ACEE82FD116066BB0519708FCEFD2A601A4 ArticleID:ACPS412 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0001-690X 1600-0447 |
DOI: | 10.1111/j.1600-0447.1997.tb09941.x |