The role of FOXO3 polymorphisms in susceptibility to tuberculosis in a Chinese population

• Published in: Molecular genetics & genomic medicine Vol. 7; no. 8; pp. e770 - n/a
• Main Authors: Wang, Bo, Wang, Yuhe, Wang, Li, He, Xue, He, Yongjun, Bai, Mei, Zhu, Linhao, Zheng, Jianwen, Yuan, Dongya, Jin, Tianbo
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2019; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Age; Asian Continental Ancestry Group - genetics; Autoimmune diseases; Case-Control Studies; China; Confidence intervals; Deoxyribonucleic acid; Disease; DNA; Ethics; Female; Forkhead Box Protein O3 - genetics; Forkhead Box Protein O3 - immunology; FOXO3; FOXO3 protein; Gender; Genes; Genetic diversity; Genetic Predisposition to Disease - genetics; Genetic variance; Genomes; Genotype; Genotype & phenotype; Genotypes; Haplotypes; Hospitals; Humans; Infectious diseases; Male; Males; Middle Aged; Mycobacteria tuberculosis; Mycobacterium tuberculosis; Odds Ratio; Original; polymorphism; Polymorphism, Single Nucleotide; Population; Regression analysis; Risk; Risk Factors; Sex Factors; Software; Statistical analysis; Studies; Tuberculosis; Tuberculosis - genetics; Tuberculosis - immunology; China; United States > US; Mycobacteria tuberculosis; polymorphism; FOXO3; infectious diseases
• ISSN: 2324-9269; 2324-9269
• DOI: 10.1002/mgg3.770

Background Tuberculosis (TB) is a significant worldwide health problem, and is caused by Mycobacteria tuberculosis. Recent studies have suggested that FOXO3 plays vital roles in the risk of immune–related infectious diseases such as TB. Methods and Results The present study aimed to evaluate FOXO3 genetic variants and TB risk. We recruited 510 TB patients and 508 healthy controls in this study. All subjects were genotyped with the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression adjusted for age and gender. Our result revealed that rs3800229 T/G and rs4946935 G/A genotypes significantly increased the risk of TB (OR = 1.34, 95% CI = 1.04–1.74, p = 0.026; OR = 1.34, 95% CI = 1.03–1.73, p = 0.029, respectively). In stratified analysis according to gender and age, we observed that rs3800229 T/G and rs4946935 G/A genotypes were associated with an increase the risk of TB among males and age ≤41 years, respectively (OR = 1.47, 95% CI = 1.06–2.04, p = 0.022 and OR = 1.45, 95% CI = 1.05–2.02, p = 0.025). Conclusions Our study showed that rs3800229 and rs4946935 in FOXO3 were associated with a risk of TB in the Chinese population. The present study aimed to evaluate FOXO3 genetic variants and tuberculosis (TB) risk. Our study found that rs3800229 and rs4946935 in FOXO3 were associated with a risk of TB in the Chinese population.