Equilibrium self-association of tropomyosin

• Published in: FEBS letters Vol. 586; no. 21; pp. 3840 - 3842
• Main Authors: Stafford, Walter F., Lee, Eunhee, Graceffa, Philip
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 02.11.2012
• Subjects: Actin; Analytical ultracentrifugation; Animals; Hydrogen-Ion Concentration; Kinetics; Muscle; Polymerization; Protein Binding; Rabbits; Solutions; Temperature; Thermodynamics; Tropomyosin; Tropomyosin - chemistry; Ultracentrifugation; Muscle; Analytical ultracentrifugation; Tropomyosin; Actin

► Skeletal muscle tropomyosin is in equilibrium between monomer, dimer and tetramer. ► Tropomyosin species type determines tropomyosin-actin binding kinetics. ► Analytical ultracentrifugation is an ideal technique to address tropomyosin dynamics. It has recently been reported that tropomyosin exists...