Hypoxia-induced hypothermia mediated by GABA in the rostral parapyramidal area of the medulla oblongata

• Published in: Neuroscience Vol. 267; pp. 46 - 56
• Main Author: Osaka, T
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 16.05.2014; Elsevier
• Subjects: Analysis of Variance; anapyrexia; Animals; Bicuculline - pharmacology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; GABA-A Receptor Antagonists - pharmacology; gamma-Aminobutyric Acid - pharmacology; Hypothermia - etiology; Hypothermia - pathology; Hypoxia - complications; Male; Medulla Oblongata - pathology; Membrane Potentials - drug effects; Membrane Potentials - physiology; Microinjections; Neurology; Neurons - drug effects; Oxygen - pharmacology; Preoptic Area; Rats; Rats, Wistar; rostral ventromedial medulla; thermoregulation; Vertebrates: nervous system and sense organs; lateral preoptic area; VO 2; parapyramidal region; rRPa; skin temperature of the tail; T s; rate of whole-body CO 2 production; gamma-aminobutyric acid; LPO; rostral ventromedial medulla; bicuculline methiodide; body core temperature; preoptic area; thermoregulation; VCO 2; T c; GABA; PPy; anapyrexia; rate of whole-body O 2 consumption; BMI; rostral raphe pallidus; Tc; VO2; VCO2; Ts; Oxygen; Central nervous system; Thermoregulation; Environmental factor; Encephalon; Neurotransmitter; Hypoxia; Medulla oblongata; Hypothermia
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.02.035

Highlights • Microinjection of GABA into the parapyramidal (PPy) region elicited hypothermia. • Injection of bicuculline into the PPy elicited no apparent change in body temperature. • Hypoxia-induced hypothermia is blocked by pretreatment of the PPy with bicuculline. • Hypoxia-induced hypothermia is mediated by GABA in the PPy.