Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo

• Published in: Neuroscience Vol. 223; pp. 114 - 123
• Main Authors: Sun, H.H, Saheb-Al-Zamani, M, Yan, Y, Hunter, D.A, Mackinnon, S.E, Johnson, P.J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 25.10.2012; Elsevier
• Subjects: Analysis of Variance; Animals; Benzoquinones - pharmacology; Benzoquinones - therapeutic use; Biological and medical sciences; Cysteine Proteinase Inhibitors - pharmacology; Cysteine Proteinase Inhibitors - therapeutic use; Drug Synergism; FK-506; Fundamental and applied biological sciences. Psychology; geldanamycin; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - therapeutic use; Lactams, Macrocyclic - pharmacology; Lactams, Macrocyclic - therapeutic use; live imaging; Locomotion - drug effects; Muscle Strength - drug effects; nerve regeneration; Nerve Regeneration - drug effects; Neurology; Peripheral Nerve Injuries - drug therapy; Peripheral Nerve Injuries - physiopathology; Rats; Rats, Transgenic; Recovery of Function - drug effects; tacrolimus; Tacrolimus - pharmacology; Tacrolimus - therapeutic use; Thy1-GFP rat; Time Factors; Vertebrates: nervous system and sense organs; EPL; FKBP-52; FK506-binding protein 52; Wallerian degeneration; DMSO; tacrolimus; experimental print length; Normal print length; Thy1-GFP rat; NPL; PLF; WD; live imaging; GFP; Hsp90; print length factor; dimethyl sulfoxide; geldanamycin; Green fluorescent protein; FK-506; nerve regeneration; GA; heat shock protein 90; Peripheral nerve; Rat; Rodentia; Geldanamycin; Regeneration; Vertebrata; Mammalia; Tacrolimus; Animal; Imaging
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.07.026

Highlights ► Geldanamycin accelerates peripheral nerve regeneration in vivo. ► Geldanamycin treatment is less toxic than treatment with FK-506. ► FK-506 likely accelerates nerve regeneration through two parallel mechanisms.