Optimization of Single-Dose VSV-Based COVID-19 Vaccination in Hamsters

• Published in: Frontiers in immunology Vol. 12; p. 788235
• Main Authors: O'Donnell, Kyle L, Clancy, Chad S, Griffin, Amanda J, Shifflett, Kyle, Gourdine, Tylisha, Thomas, Tina, Long, Carrie M, Furuyama, Wakako, Marzi, Andrea
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.01.2022
• Subjects: Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; Chlorocebus aethiops; COVID-19 - blood; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Cricetinae; Disease Models, Animal; Ebolavirus - genetics; Ebolavirus - immunology; Female; Humans; Immunogenicity, Vaccine; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunology; Male; Pandemics - prevention & control; Plasmids; rVSV-ZEBOV GP; SARS-CoV-2; SARS-CoV-2 - immunology; severe acute respiratory syndrome coronavirus-2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; T-Lymphocytes - immunology; Treatment Outcome; Vaccination - methods; Vero Cells; Vesicular stomatitis Indiana virus - genetics; Vesicular stomatitis Indiana virus - immunology; vesicular stomatitis virus; VSV-EBOV; VSV-SARS2; rVSV-ZEBOV GP; SARS-CoV-2; severe acute respiratory syndrome coronavirus-2; VSV-EBOV; VSV-SARS2; vesicular stomatitis virus

The ongoing COVID-19 pandemic has resulted in global effects on human health, economic stability, and social norms. The emergence of viral variants raises concerns about the efficacy of existing vaccines and highlights the continued need for the development of efficient, fast-acting, and cost-effect...