Recent Advances in the Aging Microenvironment of Breast Cancer

Aging is one of the risk factors for advanced breast cancer. With the increasing trend toward population aging, it is important to study the effects of aging on breast cancer in depth. Cellular senescence and changes in the aging microenvironment in vivo are the basis for body aging and death. In th...

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Published inCancers Vol. 14; no. 20; p. 4990
Main Authors Jiang, Xiaocong, Shen, Haixing, Shang, Xi, Fang, Jianwen, Lu, Yuexin, Lu, Yue, Zheng, Jingyan, Fu, Peifen
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2022
MDPI
Subjects
Adipocytes
Aging
Breast cancer
Cell growth
Cell proliferation
Chemokines
Collagen
Cytokines
Endothelial cells
Enzymes
Epigenetics
Extracellular matrix
Fibroblasts
Growth factors
Health aspects
Homeostasis
Interleukin 6
Interleukin 8
Kinases
Ligands
Metastases
Metastasis
Microenvironments
Phenotypes
Review
Reviews
Risk factors
Senescence
Stromal cells
tumor microenvironment
Tumor necrosis factor-TNF
China
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Summary:Aging is one of the risk factors for advanced breast cancer. With the increasing trend toward population aging, it is important to study the effects of aging on breast cancer in depth. Cellular senescence and changes in the aging microenvironment in vivo are the basis for body aging and death. In this review, we focus on the influence of the aging microenvironment on breast cancer. Increased breast extracellular matrix stiffness in the aging breast extracellular matrix can promote the invasion of breast cancer cells. The role of senescence-associated secretory phenotypes (SASPs) such as interleukin-6 (IL-6), IL-8, and matrix metalloproteases (MMPs), in breast cancer cell proliferation, invasion, and metastasis is worthy of exploration. Furthermore, the impact of senescent fibroblasts, adipocytes, and endothelial cells on the mammary matrix is discussed in detail. We also list potential targets for senotherapeutics and senescence-inducing agents in the aging microenvironment of breast cancer. In conclusion, this review offers an overview of the influence of the aging microenvironment on breast cancer initiation and progression, with the aim of providing some directions for future research on the aging microenvironment in breast cancer.
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ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14204990