Mnemonic representations of transient stimuli and temporal sequences in the rodent hippocampus in vitro
A primary function of the brain is the storage and retrieval of information. Except for working memory, where extracellular recordings have shown persistent discharges during delay-response tasks, it has been difficult to link memories with changes in individual neurons or specific synaptic connecti...
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Published in | Nature neuroscience Vol. 15; no. 10; pp. 1430 - 1438 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
Nature Publishing Group
01.10.2012
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Subjects | |
Online Access | Get full text |
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Summary: | A primary function of the brain is the storage and retrieval of information. Except for working memory, where extracellular recordings have shown persistent discharges during delay-response tasks, it has been difficult to link memories with changes in individual neurons or specific synaptic connections. We found that transient stimuli are reliably encoded in the ongoing activity of brain tissue in vitro. Patterns of synaptic input onto dentate hilar neurons predicted which of four pathways were stimulated with an accuracy of 76% and performed significantly better than chance for >15 s. Dentate gyrus neurons were also able to accurately encode temporal sequences using population representations that were robust to variation in sequence interval. These results demonstrate direct neural encoding of temporal sequences in the spontaneous activity of brain tissue and suggest a local circuit mechanism that may contribute to diverse forms of short-term memory. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 1097-6256 1546-1726 |
DOI: | 10.1038/nn.3208 |