Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue

Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 752962
Main Authors Li, Ping, Ma, Yuanzheng, Yu, Chengwei, Wu, Shoutong, Wang, Kai, Yi, Hongyang, Liang, Weizheng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.10.2021
Subjects
age-related diseases
aging
autophagy
brain
Cell and Developmental Biology
eye
skeletal muscle
eye
age-related diseases
autophagy
liver
aging
brain
skeletal muscle
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Abstract Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.
AbstractList Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.
Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.
Author Liang, Weizheng
Li, Ping
Yu, Chengwei
Yi, Hongyang
Ma, Yuanzheng
Wang, Kai
Wu, Shoutong
AuthorAffiliation 6 Harbin Institute of Technology , Harbin , China
3 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China
2 Department of Physiology, Guangxi University of Chinese Medicine , Nanning , China
1 College of Life Sciences and Health, Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology , Wuhan , China
5 Shenzhen Children’s Hospital , Shenzhen , China
4 School of Future Technology, University of Chinese Academy of Sciences , Beijing , China
AuthorAffiliation_xml – name: 2 Department of Physiology, Guangxi University of Chinese Medicine , Nanning , China
– name: 1 College of Life Sciences and Health, Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology , Wuhan , China
– name: 5 Shenzhen Children’s Hospital , Shenzhen , China
– name: 4 School of Future Technology, University of Chinese Academy of Sciences , Beijing , China
– name: 6 Harbin Institute of Technology , Harbin , China
– name: 3 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China
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Keywords eye
age-related diseases
autophagy
liver
aging
brain
skeletal muscle
Language English
License Copyright © 2021 Li, Ma, Yu, Wu, Wang, Yi and Liang.
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Edited by: Shou-Long Deng, Chinese Academy of Medical Sciences and Peking Union Medical College, China
This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology
These authors have contributed equally to this work and share first authorship
Reviewed by: Jiali Deng, Shanghai University, China; Qianqian Cao, Nantong University, China
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Snippet Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a...
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SubjectTerms age-related diseases
aging
autophagy
brain
Cell and Developmental Biology
eye
skeletal muscle
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Title Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue
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