Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue
Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence...
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Published in | Frontiers in cell and developmental biology Vol. 9; p. 752962 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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28.10.2021
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Abstract | Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver. |
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AbstractList | Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver. Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver. |
Author | Liang, Weizheng Li, Ping Yu, Chengwei Yi, Hongyang Ma, Yuanzheng Wang, Kai Wu, Shoutong |
AuthorAffiliation | 6 Harbin Institute of Technology , Harbin , China 3 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China 2 Department of Physiology, Guangxi University of Chinese Medicine , Nanning , China 1 College of Life Sciences and Health, Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology , Wuhan , China 5 Shenzhen Children’s Hospital , Shenzhen , China 4 School of Future Technology, University of Chinese Academy of Sciences , Beijing , China |
AuthorAffiliation_xml | – name: 2 Department of Physiology, Guangxi University of Chinese Medicine , Nanning , China – name: 1 College of Life Sciences and Health, Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology , Wuhan , China – name: 5 Shenzhen Children’s Hospital , Shenzhen , China – name: 4 School of Future Technology, University of Chinese Academy of Sciences , Beijing , China – name: 6 Harbin Institute of Technology , Harbin , China – name: 3 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China |
Author_xml | – sequence: 1 givenname: Ping surname: Li fullname: Li, Ping organization: College of Life Sciences and Health, Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, China – sequence: 2 givenname: Yuanzheng surname: Ma fullname: Ma, Yuanzheng organization: Department of Physiology, Guangxi University of Chinese Medicine, Nanning, China – sequence: 3 givenname: Chengwei surname: Yu fullname: Yu, Chengwei organization: School of Future Technology, University of Chinese Academy of Sciences, Beijing, China – sequence: 4 givenname: Shoutong surname: Wu fullname: Wu, Shoutong organization: Shenzhen Children's Hospital, Shenzhen, China – sequence: 5 givenname: Kai surname: Wang fullname: Wang, Kai organization: Shenzhen Children's Hospital, Shenzhen, China – sequence: 6 givenname: Hongyang surname: Yi fullname: Yi, Hongyang organization: Harbin Institute of Technology, Harbin, China – sequence: 7 givenname: Weizheng surname: Liang fullname: Liang, Weizheng organization: Harbin Institute of Technology, Harbin, China |
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Keywords | eye age-related diseases autophagy liver aging brain skeletal muscle |
Language | English |
License | Copyright © 2021 Li, Ma, Yu, Wu, Wang, Yi and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Shou-Long Deng, Chinese Academy of Medical Sciences and Peking Union Medical College, China This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology These authors have contributed equally to this work and share first authorship Reviewed by: Jiali Deng, Shanghai University, China; Qianqian Cao, Nantong University, China |
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Title | Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue |
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