Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue
Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence...
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Published in | Frontiers in cell and developmental biology Vol. 9; p. 752962 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
28.10.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Shou-Long Deng, Chinese Academy of Medical Sciences and Peking Union Medical College, China This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology These authors have contributed equally to this work and share first authorship Reviewed by: Jiali Deng, Shanghai University, China; Qianqian Cao, Nantong University, China |
ISSN: | 2296-634X 2296-634X |
DOI: | 10.3389/fcell.2021.752962 |