Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue

Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence...

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Published inFrontiers in cell and developmental biology Vol. 9; p. 752962
Main Authors Li, Ping, Ma, Yuanzheng, Yu, Chengwei, Wu, Shoutong, Wang, Kai, Yi, Hongyang, Liang, Weizheng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.10.2021
Subjects
age-related diseases
aging
autophagy
brain
Cell and Developmental Biology
eye
skeletal muscle
eye
age-related diseases
autophagy
liver
aging
brain
skeletal muscle
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Summary:Autophagy is an evolutionary conserved degradative process contributing to cytoplasm quality control, metabolic recycling and cell defense. Aging is a universal phenomenon characterized by the progressive accumulation of impaired molecular and reduced turnover of cellular components. Recent evidence suggests a unique role for autophagy in aging and age-related disease. Indeed, autophagic activity declines with age and enhanced autophagy may prevent the progression of many age-related diseases and prolong life span. All tissues experience changes during aging, while the role of autophagy in different tissues varies. This review summarizes the links between autophagy and aging in the whole organism and discusses the physiological and pathological roles of autophagy in the aging process in tissues such as skeletal muscle, eye, brain, and liver.
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Edited by: Shou-Long Deng, Chinese Academy of Medical Sciences and Peking Union Medical College, China
This article was submitted to Cell Death and Survival, a section of the journal Frontiers in Cell and Developmental Biology
These authors have contributed equally to this work and share first authorship
Reviewed by: Jiali Deng, Shanghai University, China; Qianqian Cao, Nantong University, China
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.752962