Role of the Extracellular Traps in Central Nervous System

It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, e...

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Published inFrontiers in immunology Vol. 12; p. 783882
Main Authors Wu, Xinyan, Zeng, Hanhai, Cai, Lingxin, Chen, Gao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.11.2021
Subjects
Animals
Blood-Brain Barrier - cytology
Blood-Brain Barrier - immunology
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
blood–brain barrier (BBB)
CNS
Disease Models, Animal
extracellular traps
Extracellular Traps - immunology
Extracellular Traps - metabolism
Humans
Immunology
Microglia - cytology
Microglia - immunology
Microglia - metabolism
Microglia - pathology
neurodegenaration
neuroinflammation
Neuroinflammatory Diseases - immunology
Neuroinflammatory Diseases - pathology
stroke
CNS
extracellular traps
neurodegenaration
neuroinflammation
stroke
blood–brain barrier (BBB)
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Summary:It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, eosinophils, and mast cells. With the development of research related to central nervous system, the role of ETs has been valued in neuroinflammation, blood-brain barrier, and other fields. Meanwhile, it has been found that microglial cells as the resident immune cells of the central nervous system can also release ETs, updating the original understanding. This review aims to clarify the role of the ETs in the central nervous system, especially in neuroinflammation and blood-brain barrier.
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This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology
Reviewed by: Pio Conti, University of Studies G. d’Annunzio Chieti and Pescara, Italy; Vadim V. Sumbayev, University of Kent, United Kingdom
Edited by: Devin William McBride, University of Texas Health Science Center at Houston, United States
These authors have contributed equally to this work and share first authorship
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.783882