Comprehensive phylogenetic reconstructions of Rift Valley fever virus: the 2010 northern Mauritania outbreak in the Camelus dromedarius species

Rift valley fever (RVF) is a mosquito-borne disease of domestic and wild ruminants caused by RVF virus (RVFV), a phlebovirus (Bunyaviridae). RVF is widespread in Sub-Saharan Africa. In September of 2010, an RVF outbreak occurred in northern Mauritania involving mass abortions in small ruminants and...

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Published inVector borne and zoonotic diseases (Larchmont, N.Y.) Vol. 14; no. 12; p. 856
Main Authors El Mamy, Ahmed B, Lo, Modou M, Thiongane, Yaya, Diop, Mariame, Isselmou, Katia, Doumbia, Baba, Baba, Mohammed Ould, El Arbi, Ahmed S, Lancelot, Renaud, Kane, Y, Albina, Emmanuel, Cêtre-Sossah, Catherine
Format Journal Article
LanguageEnglish
Published United States 01.12.2014
Subjects
Animals
Camelus - virology
Disease Outbreaks
Mauritania - epidemiology
Phylogeny
Rain
Rift Valley Fever - epidemiology
Rift Valley Fever - virology
Rift Valley fever virus - classification
Rift Valley fever virus - genetics
RNA, Viral - analysis
Phylogenetic analysis
Rift Valley fever virus
Mauritania
Camelus dromedarius
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Summary:Rift valley fever (RVF) is a mosquito-borne disease of domestic and wild ruminants caused by RVF virus (RVFV), a phlebovirus (Bunyaviridae). RVF is widespread in Sub-Saharan Africa. In September of 2010, an RVF outbreak occurred in northern Mauritania involving mass abortions in small ruminants and camels (Camelus dromedarius) and at least 63 human clinical cases, including 13 deaths. In camels, serological prevalence was 27.5-38.5% (95% confidence interval, n=279). For the first time, clinical signs other than abortions were reported in this species, including hemorrhagic septicemia and severe respiratory distress in animals. We assessed the presence of RVFV in camel sera sampled during this outbreak and generated whole-genome sequences of RVFV to determine the possible origin of this RVFV strain. Phylogenetic analyses suggested a shared ancestor between the Mauritania 2010 strain and strains from Zimbabwe (2269, 763, and 2373), Kenya (155_57 and 56IB8), South Africa (Kakamas, SA75 and SA51VanWyck), Uganda (Entebbe), and other strains linked to the 1987 outbreak of RVF in Mauritania (OS1, OS3, OS8, and OS9).
ISSN:1557-7759
DOI:10.1089/vbz.2014.1605