A cerebello-olivary signal for negative prediction error is sufficient to cause extinction of associative motor learning

The brain generates negative prediction error (NPE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing learned behaviors when they are no longer useful. Neurons encoding NPE have been reported in multiple brain regions. Here, we use an optogenetic approa...

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Bibliographic Details
Published inNature neuroscience Vol. 23; no. 12; pp. 1550 - 1554
Main Authors Kim, Olivia A, Ohmae, Shogo, Medina, Javier F
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.12.2020
Subjects
Animals
Association Learning - physiology
Brain
Cerebellum - physiology
Experiments
Extinction (Psychology)
Extinction behavior
Extinction, Psychological - physiology
gamma-Aminobutyric Acid - physiology
Lasers
Learning
Mental health
Mice
Motor ability
Motor skill learning
Motor Skills - physiology
Neural circuitry
Neural Pathways - physiology
Neurogenesis
Neurons
Neurons - physiology
Neurosciences
Observations
Ocular Physiological Phenomena
Olivary Nucleus - physiology
Optogenetics
Physical Stimulation
Psychological aspects
Psychological research
γ-Aminobutyric acid
United States
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Summary:The brain generates negative prediction error (NPE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing learned behaviors when they are no longer useful. Neurons encoding NPE have been reported in multiple brain regions. Here, we use an optogenetic approach to demonstrate that GABAergic cerebello-olivary neurons can generate a powerful NPE signal, capable of causing extinction of conditioned motor responses on its own.
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AUTHOR CONTRIBUTIONS
O.K. & J.M. designed the experiments. J.M. supervised the project. O.K. performed virus injection and optical fiber implant surgeries, and conducted all behavior/optogenetics experiments. S.O. performed all electrophysiology-related surgery and experiments. O.K. analyzed and curated all original data collected for this publication. S.O. curated data included from a previous publication. O.K. & J.M. wrote the original draft of the paper. J.M., O.K., & S.O. revised and edited the paper.
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-020-00732-1