Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-γ) Promoter and Subsequent Downregulation of IFN-γ Production

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Published inMolecular and Cellular Biology Vol. 18; no. 9; pp. 5166 - 5177
Main Authors Mikovits, Judy A., Young, Howard A., Vertino, Paula, Issa, Jean-Pierre J., Pitha, Paula M., Turcoski-Corrales, Susan, Taub, Dennis D., Petrow, Cari L., Baylin, Stephen B., Ruscetti, Francis W.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.09.1998
Taylor & Francis
Subjects
CD4-Positive T-Lymphocytes - cytology
CD4-Positive T-Lymphocytes - physiology
CD4-Positive T-Lymphocytes - virology
Cell Cycle
Cell Line
Cell Transformation, Viral
Clone Cells
Cytokines - biosynthesis
DNA Methylation
DNA Modification Methylases - biosynthesis
Gene Expression
Gene Expression Regulation, Enzymologic
HIV Core Protein p24 - biosynthesis
HIV-1 - immunology
HIV-1 - physiology
Human immunodeficiency virus 1
Humans
Interferon-gamma - biosynthesis
Interferon-gamma - genetics
Polymerase Chain Reaction
Promoter Regions, Genetic
T-Lymphocytes - cytology
T-Lymphocytes - immunology
T-Lymphocytes - virology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - virology
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Summary:Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue MCB About MCB Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MCB RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0270-7306 Online ISSN: 1098-5549 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to MCB .asm.org, visit: MCB       
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Corresponding author. Mailing address: P.O. Box B, Bldg. 567, Rm. 253, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201. Phone: (301) 846-5610. Fax: (301) 846-7034. E-mail: Mikovits@fcrfv1.ncifcrf.gov.
ISSN:0270-7306
1098-5549
1098-5549
DOI:10.1128/MCB.18.9.5166