Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12

• Published in: American journal of human genetics Vol. 70; no. 3; pp. 593 - 603
• Main Authors: Gretarsdottir, Solveig, Sveinbjörnsdottir, Sigurlaug, Jonsson, Hjörtur H., Jakobsson, Finnbogi, Einarsdottir, Elisabet, Agnarsson, Uggi, Shkolny, Dana, Einarsson, Gisli, Gudjonsdottir, Herdis M., Valdimarsson, Einar M., Einarsson, Olafur B., Thorgeirsson, Gudmundur, Hadzic, Radinka, Jonsdottir, Sif, Reynisdottir, Sigridur Th, Bjarnadottir, Sigrun M., Gudmundsdottir, Thorunn, Gudlaugsdottir, Gudrun J., Gill, Ramanjit, Lindpaintner, Klaus, Sainz, Jesus, Hannesson, Helgi H., Sigurdsson, Gunnar Th, Frigge, Michael L., Kong, Augustine, Gudnason, Vilmundur, Stefansson, Kari, Gulcher, Jeffrey R.
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.03.2002; University of Chicago Press; The American Society of Human Genetics
• Subjects: Alleles; Biological and medical sciences; Chromosome Mapping; Chromosomes, Human, Pair 5 - genetics; Diabetes Complications; Diabetes Mellitus - genetics; Female; Genetic Markers - genetics; Genetic Predisposition to Disease; Genome, Human; Humans; Hypercholesterolemia - complications; Hypercholesterolemia - genetics; Hypertension - complications; Hypertension - genetics; Iceland; Lod Score; Male; Medical sciences; Neurology; Pedigree; Risk Factors; Stroke - complications; Stroke - genetics; Vascular diseases and vascular malformations of the nervous system; Iceland; Human; Nervous system diseases; Stroke; Linkage; Long arm; Family study; Pathogenesis; Clinical form; Cardiovascular disease; Chromosome B5; Genetic determinism; Cerebral disorder; Vascular disease; Gene; Central nervous system disease; Risk factor; Database; Genome; Cerebrovascular disease; Comparative study
• ISSN: 0002-9297; 1537-6605
• DOI: 10.1086/339252

Stroke is one of the most complex diseases, with several subtypes, as well as secondary risk factors, such as hypertension, hyperlipidemia, and diabetes, which, in turn, have genetic and environmental risk factors of their own. Here, we report the results of a genomewide search for susceptibility genes for the common forms of stroke. We cross-matched a population-based list of patients with stroke in Iceland with an extensive computerized genealogy database clustering 476 patients with stroke within 179 extended pedigrees. Linkage to 5q12 was detected, and the LOD score at this locus meets the criteria for genomewide significance (multipoint allele-sharing LOD score of 4.40, P=3.9×10 −6). A 20-cM region on 5q was physically and genetically mapped to obtain accurate marker order and intermarker distances. This locus on 5q12, which we have designated as “ STRK1,” does not correspond to known susceptibility loci for stroke or for its risk factors and represents the first mapping of a locus for common stroke.