Normal Ventricular and Regional Blood Flow Volumes and Native T1 Values in Healthy Japanese Children Obtained from Comprehensive Cardiovascular Magnetic Resonance Imaging

• Published in: International Heart Journal Vol. 64; no. 4; pp. 663 - 671
• Main Authors: Ishikawa, Yuichi, Urabe, Hiroaki, Yamada, Yuya, Yamamura, Kenichiro, Tao, Katsuo, Suzuki, Sayo, Muraji, Shota, Kuraoka, Ayako, Sagawa, Koichi
• Format: Journal Article
• Language: English
• Published: Japan International Heart Journal Association 29.07.2023; Japan Science and Technology Agency
• Subjects: 2-dimensional; Age; Blood flow; Cardiovascular diseases; Children; Flow volume; Heart; Liver; Magnetic resonance imaging; Normal heart; Pediatrics; Phase contrast; T1 mapping; Ventricle; 2-dimensional; Flow volume; Normal heart; Phase contrast; T1 mapping
• ISSN: 1349-2365; 1349-3299
• DOI: 10.1536/ihj.23-022

Age-related mean and reference ranges for ventricular volumes and mass, regional blood flow measurements, and T1 values using cardiovascular magnetic resonance (CMR) imaging are yet to be established for the pediatric population. Especially in infants and toddlers, no consistent flow volume sets or T1 values have been reported. The purpose of this study was to determine the relevant normal values.Twenty-three children (aged 0.1-15.3 years) without cardiovascular diseases were included. Comprehensive CMR imaging including cine, 2-dimensional phase-contrast, and native T1 mapping, were performed. Ventricular volumes and masses, 11 sets of regional blood flow volumes, and myocardial and liver T1 values were measured. All intraclass correlation coefficient values were > 0.94, except for the right ventricular mass (0.744), myocardial (0.868) and liver T1 values (0.895), reflecting good to excellent agreement between rates.Regression analysis showed an exponential relationship between body surface area (BSA) and ventricular volumes, mass, and regional blood flow volumes (normal value = a*BSAb). Left ventricular myocardial T1 values were regressed on linear regression with age (normal value = -7.39*age + 1091), and hepatic T1 values were regressed on a quadratic function of age (normal value = 0.923*age2 -18.012*age + 613).Comparison of the 2 different methods for the same physical quantities by Bland-Altman plot showed no difference except that the right ventricular stroke volume was 1.5 mL larger than the main pulmonary trunk flow volume.This study provides the normal values for comprehensive CMR imaging in Japanese children.